Synthetic Studies on Pyridoxine Derivatives. II. Synthesis of 3-(3-Hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl) methyl-4-methyl-5-substitutedthiazoline-2-thiones

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概要

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• Syntheses of some pyridoxine derivatives having a thiazoline ring or a thiazolium ring at the 5-position are described. 3-(3-Hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl)-methyl-5-methylthiazoline-2-thione (IX) was synthesized from α^4,3-O-isopropylideneisopyridoxamine (VII), carbon disulfide, ammonium hydroxide, and chloropropanone. Similarly X, XI, and XII were obtained by employing appropriate alkyl chloride instead of chloropropanone. Treatment of IX, X, XI, and XII with 30% hydrogen peroxide and 35% hydrochloric acid gave 3-(3-hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl) methyl-4-methyl-5-substitutedthiazoliumchloride hydrochlorides (XIII, XIV, XV, XVI).

• 公益社団法人日本薬学会の論文
• 1977-01-25

著者

• 伊藤 磯雄

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 植田 泰誠

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  名古屋市立大学薬学部

• 鈴木 健司

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 伊藤 磯雄

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 黒柳 吉雄

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 黒柳 吉雄

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 植田 泰誠

  Faculty Of Pharmaceutical Sciences Nagoya City University

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