Diphenylmethane誘導体の研究(第2報)N-Substituted-1-(3,4-dimethoxyphenyl)-1-(2-, 3- or 4-substituted phenyl) methylamine誘導体の合成

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概要

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• N-Alkyl-1-(3,4-dimethoxyphenyl)-1-(2-, 3-, or 4-substituted phenyl) methylamines (XI-XLVI) were synthesized from 3,4-dimethoxybenzaldehyde and 2-, 3-, or 4-substituted bromobenzene using the Grignard reaction and halogenation, followed by amination with various alkylamines. Of the compounds synthesized and tested, XVIII was found to possess a weak antitussive activity, and XVI and XIX showed a marked local anesthesic activity.

• 公益社団法人日本薬学会の論文
• 1975-01-25

著者

• 伊藤 磯雄

  名古屋市立大学薬学部

• 織田 範一

  名古屋市立大学薬学部

• 植田 泰誠

  名古屋市立大学薬学部

• 植田 泰誠

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 若山 孝熈

  マルコ製薬株式会社

• 若山 孝熈

  マルコ製薬

• 若山 孝熈

  名古屋市立大学薬学部

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