β-ケト酸誘導体の合成研究(第1報) : 2-Bromo-3-oxoglutaric Esterの求核試薬に対する反応性
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Methyl 2-bromo-3-oxoglutarate (III) was prepared from methyl 3-oxoglutarate (II), and various nucleophilic reagents were reacted with active bromine atom in α-position of III to obtain isoxazole derivatives (IV〜VI), 2-aminooxazole derivatives (VII〜XI), 2-amino-thiazole derivatives (XII〜XV), and 2-anilinooxazole derivatives (XVI〜XVIII).
- 公益社団法人日本薬学会の論文
- 1966-04-25
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