Synthesis of Pyrazolone Derivatives. XXVI. Reaction of 1-Methyl-2-phenyl-1,2,3,10-tetrahydro-4H-benzo [6,7] thiepino [3,4-c] pyrazole-3,4-dione with Dimethyl Acetylenedicarboxylate
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概要
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The Michael and the Diels-Alder reactions of 1-methyl-2-phenyl-1,2,3,10-tetrahydro-4H-benzo [6,7] thiepino [3,4-c] pyrazole-3,4-dione (1) with dimethyl acetylenedicarboxylate (2) were examined, and the fascinating reactions which gave two novel heterocycles were found : dimethyl 1,2-dihydro-1-methyl-3-oxo-2-phenyl-3H-benzothieno [3,2-e] indazole-9,10-dicarboxylate (3) and dimethyl 1,2-dihydro-4-hydroxy-1-methyl-3-oxo-2-phenyl-3H-[2] benzothiopyrano [4,3,2-f, g] indazole-8,9-dicarboxylate (15). The mechanisms of the formations of 3 and 15 were discussed. For pharmacological evaluation some N, N-dimethylethylenediamine derivatives of 3 and 15 were synthesized.
- 公益社団法人日本薬学会の論文
- 1976-04-25
著者
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飯高 洋一
Faculty of Pharmaceutical Sciences, The University of Tokyo
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伊藤 磯雄
Faculty of Pharmaceutical Sciences, Nagoya City University
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伊藤 磯雄
名古屋市立大学薬学部
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飯高 洋一
School Of Medicine Teikyo University
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伊藤 磯雄
Faculty Of Pharmaceutical Sciences Nagoya City University
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植田 泰誠
Faculty Of Pharmaceutical Sciences Nagoya City University
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飯高 洋一
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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