Microbiologically Modified Chiral Synthon. II. : 4,9-Dimethyl-3,7-dioxo-Δ^<4(10)>-octalin for Formal Total Syntheses of Certain C(8) Oxygenated Sesquiterpenoids

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概要

• 論文の詳細を見る

• 4,(9S)- (2a) and 4,(9R)-dimethyl-(7S)-hydroxy-3-oxo-Δ^<4(10)>-octalin (4a) were prepared in high optical purity (>99%ee) and in moderate yield by asymmetric reduction of the corresponding racemic diketone (±)-1 using yeasts. These compounds were used for formal total syntheses of C(8) oxygenated sesquiterpenoids such as (-)-artemisin, (-)-yomogin, (-)-3-oxodiplophyllin, β-elemenone, (+)-isotelekin, (+)-cuauhtemone and 4-epi-aubergenon.

• 公益社団法人日本薬学会の論文
• 1989-04-25

著者

• 大倉 多美子

  Pharmaceutical Institute School Of Medicine Keio University

• 飯高 洋一

  Nishi-tokyo Science University

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 秋田 弘幸

  School of Pharmaceutical Sciences, Toho University

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 稲山 誠一

  Pharmaceutical Institute, School of Medicine, Keio University

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 大石 武

  理研:(現)明治薬科大学

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 清水 信子

  Pharmaceutical Institute, School of Medicine, Keio University

• 秋田 弘幸

  Institute of Physical and Chemical Research

• 大石 武

  Institute of Physical and Chemical Research

• 稲山 誠一

  Institute Of Oriental Medical Sciences

• 稲山 誠一

  Pharmaceutical Institute School Of Medicine Keio University

• 稲山 誠一

  慶應義塾大学医学部薬化学研究所

• 清水 信子

  Pharmaceutical Institute School Of Medicine Keio University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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