Chemistry of Tremorogenic Metabolites. II. Structure Determination of Fumitremorgin B, a Tremorogenic Metabolite from Aspergillus fumigatus

元データ 1980-03-25 社団法人日本薬学会

概要

Fumitremorgin B (2), isolated from Aspergillus fumigatus together with fumitremorgin A (1), caused severe tremors and convulsion in experimental animals. The structure of fumitremorgin B was determined from the spectral data. The stereochemistry, including the absolute configuration, was determined by X-ray analysis and comparison of the ORD of proline obtained from this compound with that of authentic L-(-)-proline.

著者

飯高 洋一 Nishi-tokyo Science University
飯高 洋一 Faculty of Pharmaceutical Sciences, The University of Tokyo
鈴木 久美子 千葉大学薬学部
藤本 治宏 Research Institute for Chemobiodynamics, Chiba University
鈴木 久美子 Hoshi College of Pharmacy
藤本 治宏 千葉大院薬
秋山 敏行 Faculty Of Pharmaceutical Sciences University Of Tokyo
飯高 洋一 Faculty Of Pharmaceutical Sciences University Of Tokyo
飯高 洋一 西東京科学大学理工学部
Yamazaki M School Of Pharmaceutical Sciences Kinki University
飯高 洋一 Faculty Of Pharmaceutical Sciences The University Of Tokyo

関連論文

▼もっと見る