Studies on Metal Complexes of Isocytosine Derivatives : The Crystal Structures of Mercury(II) and Nickel(II) Complexes of 2-Hydrazino-4-hydroxy-6-methylpyrimidine

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• The preparation and crystal structure of mercury(II) and nickel(II) complexes of 2-hydrazino-4-hydroxy-6-methylpyrimidine (LH) are described. The crystal of the mercury(II) complex, [HgCl_4](LHH)_2・2H_2O is triclinic with a=7.481(2), b=19.535(6), c=7.482(2)Å, α=94.77(3)°, β=106.28(5)°, γ=85.24(3)°, V=1043.8(6)Å^3,D_x=2.102g・cm^<-3>, Z=2,and space group P1^^-. The atomic parameters were refined to a final R value of 0.044 for 3115 reflections. In the mercury(II) complex, one [HgCl_4]^<2-> group which completes a regular tetrahedral coordination and two LHH^+ molecules which take a keto form (>C(4)=O), constitute a double salt type structure, in which both units are bound together hydrogen bonds. It is notable that two different modes of stackings along the a and c axis are found between pyrimidine rings in the crystal. The crystal of the nickel(II) complex, [Ni(LH)_2(H_2O)_2]Cl_2・2H_2O is triclinic with a=8.911(2), b=9.197(2), c=6.791(1)Å, α=93.41(3)°, β=102.31(3)°, γ=114.32(4)°, V=490.1(3)Å^3,D_x=1.633g・cm^<-3>. Z=1,and space group P1^^-. The atomic parameters were refined to a final R value of 0.049 for 1310 reflections. The nickel(II) ion completes an octahedral coordination with two ring nitrogen N(3) and two hydrozino N_<amino> nitrogen atmos of the two neighboring ligand molecules and two water molecules. The chloride ion is not bonded to nickel(II) ion but is hydrogen bonded to N(1)-H of the pyrimidine base. The length of C(4)-O(9), 1.249,in the LH residue suggests the keto form. Therefore, in the same preparation method with excess protons, the mercury(II) complex forms a double salt type structure, [HgCl_4](LHH)_2・2H_2O, whereas the nickel(II) complex forms a chelate type structure, [Ni(LH)_2(H_2O)_2]Cl_2・2H_2O.

• 社団法人日本薬学会の論文
• 1990-04-25

著者

• 飯高 洋一

  Nishi-tokyo Science University

• 小倉 治夫

  School of Pharmaceutical Sciences, Kitasato University

• 高柳 弘明

  School of Pharmaceutical Sciences, Kitasato University

• 小倉 治夫

  北里大学

• 小倉 治夫

  School Of Pharmaceutical Sciences Kitasato University

• 高柳 弘明

  北里大学薬学部薬化学教室

• 高柳 弘明

  School Of Pharmaceutical Sciences Kitasato University

• 吉井 新

  School of Hygienic Sciences, Kitasato University

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 坂口 洋

  School of Hygienic Sciences, Kitasato University

• 宮本 久美子

  School of Hygienic Sciences, Kitasato University

• 吉井 新

  School Of Hygienic Sciences Kitasato University

• 坂口 洋

  School Of Hygienic Sciences Kitasato University

• 宮本 久美子

  School Of Hygienic Sciences Kitasato University

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