Some Novel Reactions of 1,3-Dimethyluracils. II. Studies on New Stable Pyrimidine Ring-Opened Compounds
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概要
- 論文の詳細を見る
N, N'-Dialkyl-N-[3-methoxy-3-dialkylamino-2-(3-methoxycarbonylpropioloyl) acryloyl] ureas (3) were synthesized by coupling of 1,3-dialkyl-6-(N-substituted) aminouracils (2) and dimethyl acetylenedicarboxylate (DMAD). Compounds (3) are stable crystalline materials at room temperature, but on heating in DMF, they undergo cyclization, giving rise to the pyrido [2,3-d] pyrimidine derivatives. These compounds were characterized by ^1H-nuclear magnetic resonance (NMR), ^<13>C-NMR, mass spectral and elemental analyses.
- 社団法人日本薬学会の論文
- 1982-01-25
著者
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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伊東 常男
School of Pahrmaceutical Sciences, Kitasato University
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川原 徳夫
Hokkaido Institute of Pharmaceutical Sciences
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渡辺 恭一
Sloan-kettering Instiute For Cancer Research Memorial Sloan-kettering Cancer Center:sloan-kettering
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伊東 常男
School Of Pharmaceutical Sciences Kitasato University
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川原 徳夫
北海道薬大
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