Studies on Sialic Acids. IV. : Synthesis of N-Acetyl-D-neuraminic Acid N-Nucleoside Analogs
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概要
- 論文の詳細を見る
Some N-acetyl-D-neuraminec acid nucleoside analogs were synthesized. Methyl penta-O-acetyl-N-acetyl-D-neuraminate (1) was treated with trimethylsilyl-pyrimidine or -5-fluoropyrimidine and tin(IV) chloride to give a mixture of α- and β-anomers of N-nucleoside analogs. On the other hand, methyl tetra-O-acetyl-N-acetyl-2-chloro-β-D-neuraminate was allowed to react with trimethylsilyl-pyrimidine or -5-fluoropyrimidine under the Koenigs-Knorr reaction conditions to provide the β-anomer in a fair yield. The stereochemistry of these compounds was confirmed by measurements of the rate of hydrolysis of the glycosidic bond with water.
- 公益社団法人日本薬学会の論文
- 1986-04-25
著者
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古畑 公夫
School of Pharmaceutical Sciences, Kitasato University
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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伊藤 正善
Central Research Laboratory, MECT Co., Ltd.,
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志鳥 善保
Central Research Laboratory, MECT Co., Ltd.,
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藤田 秀司
School of Pharmaceutical Sciences, Kitasato University
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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伊藤 正善
メクト中研
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志鳥 善保
メクト中研
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藤田 秀司
メクト中研
関連論文
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