Studies on Nucleoside Analogs. XIX. Reaction of D-Gluconyl Isothiocyanate with Diamines or Enamines
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概要
- 論文の詳細を見る
The reaction of phenylacetyl isothiocyanate (1a) with diamines afforded 1-substituted 3-phenylacetyl thiourea (3a-d) in good yields. Attempted ring closure of these products under thermal or basic conditions was unsuccessful. However, treatment of 3a with Ac_2O-H_3PO_4 at room temperature gave the cyclized product (5a). Similar reaction of D-gluconyl isothiocyanate (1b) with o-phenylenediamine (2a) or diaminopyrimidines (2b, c, e, f) gave the D-gluco-pentyl benzotriazepine-2-thione (7a) or D-gluco-pentyl pyrimidotriazepine-2-thiones (7b, c, e, f), respectively, in fair yields. Treatment of 1b with ethyl 3-aminocrotonate or 6-amino-1,3-dimethyluracil afforded D-gluco-pentyl thiopyrimidine (8b) or D-gluco-pentyl pyrimido [4,5-d] pyrimidine (9b), respectively.
- 社団法人日本薬学会の論文
- 1981-07-25
著者
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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高橋 洋
School Of Pharmaceutical Sciences Kitasato University
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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武田 収功
School of Pharmaceutical Sciences, Kitasato University
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武田 収功
School Of Pharmaceutical Sciences Kitasato University
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