A One-Step Synthesis of Glycosylaminoisothiazolo [3,4-d] pyrimidines and Glycosylaminoisothiazoles
スポンサーリンク
概要
- 論文の詳細を見る
The reaction of glycosyl isothiocyanates (5a-c) with 2-aminopyridine or 2-amino-4-picoline gave N-glycosyl-N'-(pyrid-2-yl) thioureide (6a) or N-glycosyl-N'-(4-methylpyrid-2-yl) thioureide (6b), respectively, in good yields ; cyclized products were not obtained. On the other hand, the reaction of glycosyl isothiocyanates (5a-c) with ethyl 3-aminocrotonate yielded ethyl 3-amino-2-glycosylthiocarbamoylcrotonates (7a-c) and glycosylaminoisothiazoles (8a-c). A similar reaction between 5a-c and 6-amino-1,3-dimethyluracil afforded glycosylaminoisothiazolo [3,4-d] pyrimidines (10a-c) in excellent yields.
- 社団法人日本薬学会の論文
- 1979-05-25
著者
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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高橋 洋
School Of Pharmaceutical Sciences Kitasato University
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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二村 典行
School of Pharmaceutical Sciences, Kitasato University
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二村 典行
School Of Pharmaceutical Sciences Kitasato University
関連論文
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