Studies on Sialic Acids. XVIII. : Synthesis of Aryl-α-glycosides of 3-Deoxy-D-glycero-D-galacto-2-nonulopyranosonic Acid (KDN)
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概要
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Condensation of sodium phenoxide, sodium p-nitrophenoxide, and sodium 4-methylumbelliferonate with benzyl (4,5,7,8,9-penta-O-acetyl-3-deoxy-D-glycero-β-D-galacto-2-nonulopyranosyl chlorid)onate under the Williamson reaction conditions gave the corresponding α-glycosides in good yields. Deprotection reaction of these α-glycosides gave sodium salts of phenyl-, p-nitrophenyl-, and 4-methylumbelliferonyl-α-glycosides of 3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic acid (KDN). The structure and stereochemistry of the glycosylation products were determined by proton nuclear magnetic resonance (^1H-NMR) and circular dichroism (CD) spectral analysis.
- 公益社団法人日本薬学会の論文
- 1989-03-25
著者
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古畑 公夫
School of Pharmaceutical Sciences, Kitasato University
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小倉 治夫
School of Pharmaceutical Sciences, Kitasato University
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古畑 公夫
北里大薬
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小倉 治夫
北里大学
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小倉 治夫
School Of Pharmaceutical Sciences Kitasato University
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中村 光延
School of Pharmaceutical Sciences, Kitasato University
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中村 光延
School Of Pharmaceutical Sciences Kitasato University
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