プロカインのーピクリン酸塩及びニピクリン酸塩の結晶構造
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概要
- 論文の詳細を見る
Procaine hydrochlorate is identified by the melting point of Procaine picrate (JP XII). Although the melting points of monopicrate (1) and dipicrates (2) of procaine have been reported, they are inconsistent each other in their reports. It is not specified 1 or 2 in JP XII. From these reasons, the crystal structures of 1 and 2 of procaine have been elucidated by X-ray crystallographic analysis and each melting point is clarified. 1 is formed through the hydrogen bond between the phenolic hydroxyl group of a picric acid molecule and the tertiary amine of a procaine molecule, and the melting point of 1 was 133-135℃ (decomp.). 2 is formed through the hydrogen bonds between the tertiary and the first amines of a procaine molecule and the phenolic hydroxyl groups of two picric acid molecules, respectively. The melting point of 2 was 152-155℃ (decomp.).
- 公益社団法人日本薬学会の論文
- 1994-01-25
著者
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高柳 弘明
北里大・薬
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古畑 公夫
北里大薬
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菅井 啓
メクト株式会社東京研究所
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高柳 弘明
北里大学薬学部薬化学教室
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高柳 弘明
School Of Pharmaceutical Sciences Kitasato University
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後藤 元彰
(株)埼玉第一製薬
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後藤 元彰
北里大学薬学部
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廣井 知佳
北里大学薬学部
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古畑 公夫
北里大学薬学部
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甲斐 俊次
北里大学薬学部
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齋藤 謹一
メクト株式会社東京研究所
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杉山 直和
メクト株式会社東京研究所
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斉藤 謹一
メクト株式会社東京研究所
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甲斐 俊次
School Of Pharmaceutical Sciences Kitasato University
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高柳 弘明
北里大学薬学部
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