25 ラクタム環コンホメーションとCotton効果の関係
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概要
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A rule about the n-π* Cotton effect of seven-membered lactam ring (lactam rule) was investigated from ORD and CD spectra of A-azatetrahydro-α-santonins and A-azasteroids derived from their oximes by the Beckmann Rearrangement. From this rule, the seven-membered lactam was classified into two types A and B. Type A should have the negative and type B should have the positive Cotton effect. Further applications of the lactam rule to four-membered lactam, azetidinones, and five-membered lactam, camphorolactams and pyrrolidones are discussed. This rule was applied to simple seven-membered lactams, (-)-menthone lactam, N-methyl-(-)-menthone lactam, and N-methyl-A-azatetrahydro-α-santonins. Conformational equilibrium of these compound was discussed on the basis of the lactam rule.
- 天然有機化合物討論会の論文
- 1973-10-01
著者
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高柳 弘明
北里大学薬学部薬化学教室
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高柳 弘明
School Of Pharmaceutical Sciences Kitasato University
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小倉 治夫
北里大学薬学部
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古畑 公夫
北里大学薬学部
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高柳 弘明
北里大学薬学部
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