Studies on Metal Complexes of Isocytosine Derivatives : The Molecular Structures of Platinum(II)and Platinum(IV)Complexes of 2-Hydrazino-4-hydroxy-6-methylpyrimidine

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概要

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• The Pt(II) and Pt(IV) complexes of 2-hydrazino-4-hydroxy-6-methylpyrimidine (LH) were synthesized and their structures investigated.We found that Pt(II) and Pt(IV) ions form novel 1 : 1 and 1 : 2 complexes with LH, respectively.The Pt(II) complex of LH, [Pt^<II>Cl_2(LH)], is a square planar complex with a Pt(II) coordination number of four.On the other hand, in the [Pt^<IV>Cl_6](LHH)_2 complex, one [Pt^<IV>Cl_6]^<2-> group forms a double salt with two LHH^+ molecules which are connected to each other by hydrogen bonds as shown by X-ray structure determination. Crystals of [Pt^<IV>Cl_6](LHH)_2,C_<10>H_<18>Cl_6N_8O_2Pt, belong to the space group P1^^- with the unit cell dimensions, a=6.825(2), b=11.496(4), c=6.775(2)Å, a=101.17(3)°, γ=85.69(3)°, V=506.(3)Å^3 and Z=1. The atomic parameters were refined to a final R value of 0.050 for 4441 reflections.The Pt(IV) ion is situated at the crystallographic center of symmetry.Six ligated Cl^- ions and two protonated LHH^+ are arranged symmetrically around the Pt(IV) ion, and the [Pt^<IV>Cl_6]^<2-> complex ion takes an octahedral cooldination geometry.

• 社団法人日本薬学会の論文
• 1989-03-25

著者

• 飯高 洋一

  Nishi-tokyo Science University

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 古畑 公夫

  School of Pharmaceutical Sciences, Kitasato University

• 小倉 治夫

  School of Pharmaceutical Sciences, Kitasato University

• 高柳 弘明

  School of Pharmaceutical Sciences, Kitasato University

• 古畑 公夫

  北里大薬

• 小倉 治夫

  北里大学

• 小倉 治夫

  School Of Pharmaceutical Sciences Kitasato University

• 高柳 弘明

  北里大学薬学部薬化学教室

• 高柳 弘明

  School Of Pharmaceutical Sciences Kitasato University

• 吉井 新

  School of Hygienic Sciences, Kitasato University

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 坂口 洋

  School of Hygienic Sciences, Kitasato University

• 坂部 譲

  School of Hygienic Sciences, Kitasato University

• 吉井 新

  School Of Hygienic Sciences Kitasato University

• 坂口 洋

  School Of Hygienic Sciences Kitasato University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 坂部 譲

  School Of Hygienic Sciences Kitasato University

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