Studies on the Terpenoids and Related Alicyclic Compounds. XXI. Formation and X-Ray Crystal Structure of a Novel Spiro Dimer of 6-Dehydroxysantoninic Acid

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概要

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• Treatment of 14-bromo-6-dehydroxysantoninic acid (1a) with 10% Na_2CO_3-acetone solution gave the lactone dimer (2), the spiro dimer (5), and a hydroxy compound (4), in 17%, 40%, and 21% yields, respectively. The molecular structure of the major product, 6-dehydroxysantoninic acid spiro dimer (5), was confirmed by X-ray crystallographic analysis. The mechanism of formation of 5 during the course of this reaction is discussed.

• 社団法人日本薬学会の論文
• 1980-11-25

著者

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 村上 昭弘

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 西谷 潔

  東京都立衛生研究所 微生物部

• 西谷 潔

  東京理科大学薬学部

• 山川 浩司

  東京理大

• 村上 昭弘

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 飯高 洋一

  西東京科学大

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 西谷 潔

  東京理大・薬

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