Studies on the Terpenoids and Related Alicyclic Compounds. XXI. Formation and X-Ray Crystal Structure of a Novel Spiro Dimer of 6-Dehydroxysantoninic Acid

元データ 1980-11-25 社団法人日本薬学会


Treatment of 14-bromo-6-dehydroxysantoninic acid (1a) with 10% Na_2CO_3-acetone solution gave the lactone dimer (2), the spiro dimer (5), and a hydroxy compound (4), in 17%, 40%, and 21% yields, respectively. The molecular structure of the major product, 6-dehydroxysantoninic acid spiro dimer (5), was confirmed by X-ray crystallographic analysis. The mechanism of formation of 5 during the course of this reaction is discussed.


飯高 洋一 Faculty of Pharmaceutical Sciences, The University of Tokyo
村上 昭弘 Faculty of Pharmaceutical Sciences, Science University of Tokyo
西谷 潔 東京都立衛生研究所 微生物部
西谷 潔 東京理科大学薬学部
山川 浩司 東京理大
村上 昭弘 Faculty Of Pharmaceutical Sciences Science University Of Tokyo
飯高 洋一 西東京科学大
飯高 洋一 Faculty Of Pharmaceutical Sciences The University Of Tokyo
西谷 潔 東京理大・薬