Studies on Organic Fluorine Compounds. XLVII. Synthesis of Trifluoromethylated Sugars through the Aldol Reaction of 2-Trimethylsilyloxy-4-trifluoromethylfuran
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概要
- 論文の詳細を見る
Lewis acid-catalyzed aldol condensation of 2-trimethylsilyloxy-4-trifluoromethylfuran (2a) with aldehydes was found to proceed in a regio- and diastereoselective manner to give the 5-substituted 4-trifluoromethyl-2 (5H)-furanone (4) in good yield. The aldol product (4a) derived from benzyloxyacetaldehyde was successfully converted to the branched sugar (12), the first reported example of a trifluoromethylated branched sugar, and its crystal structure was determined by X-ray analysis.
- 社団法人日本薬学会の論文
- 1985-10-25
著者
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田口 武夫
東京薬科大学薬学部
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小林 義郎
Tokyo College of Pharmacy
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飯高 洋一
Faculty of Pharmaceutical Sciences, The University of Tokyo
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田口 武夫
Tokyo College of Pharmacy
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小林 義郎
東京薬科大学薬学部
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飯高 洋一
School Of Medicine Teikyo University
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Taguchi T
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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榛沢 雄二
Tokyo College of Pharmacy
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河田 恒佐
Tokyo College of Pharmacy
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北川 理
Tokyo College of Pharmacy
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北川 理
東京薬科大学薬学部
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飯高 洋一
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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