Studies on the Reactions of Heterocyclic Compounds. III. Cyanation of 1,6-Naphthyridine N-Oxides
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概要
- 論文の詳細を見る
The Reissert reaction with 1,6-naphthyridine occurs at the nitrogen atom of 6-position. In the same reaction with 1,6-naphthyridine 1-oxide, 6-oxide, and 1,6-dioxide, N-oxide group reacts and gives 2-cyano-, 5-cyano-, and 2,5-dicyano-derivatives as expected. And 1,6-dioxide reacts with KCN in MeOH to give 2-methoxy-5-cyano-1,6-naphthyridine, 2-methoxy-1,6-naphthyridine-5-carboxamide, 2-methoxy-1,6-naphthyridine 6-oxide. The same recation with 1-oxide gives 1,6-naphthyridine and 2-methoxy-1,6-naphthyridine or 2-methoxy-1,6-naphthyridine-5-carboxamide. The mechanism of these novel reactions was proposed.
- 公益社団法人日本薬学会の論文
- 1969-12-25
著者
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小林 義郎
Tokyo College of Pharmacy
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佐藤 治男
Sato Institute Of Pharmaceutical Sciences
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熊懐 稜丸
Tokyo College of Pharmacy
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佐藤 治男
Tokyo College of Pharmacy
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