含フッ素生理活性物質の合成
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概要
- 論文の詳細を見る
First, characteristics of a carbon-fluorine bond from the biological point of view are summarized with some examples : mimic effect, protective fluorination, irreversible conjugation with enzyme, increased lipophilicity and so on are presented. Secondly, some approaches to biologically active compounds utilizing the above characteristics are shown by the examples of trifluoromethylated nucleoside derivatives and fluorinated vitamin D<SUB>3</SUB> analogues.
- 社団法人 有機合成化学協会の論文
著者
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田口 武夫
東京薬科大学薬学部
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小林 義郎
東京薬科大学薬学部
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熊懐 稜丸
Tokyo College of Pharmacy
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熊懐 稜丸
東京薬科大学
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小林 義郎
東京薬科大学:ダイキン工業(株)mec研究所
関連論文
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- Pharmacokinetics of Chitobiose and Chitotriose Administered Intravenously or Orally to Rats(Biopharmacy)
- Antioxidant Activities of Chitobiose and Chitotriose(Miscellaneous)
- 当代留学事情
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- Synthesis and Biological Activity of Fluorine-Modified Platelet Activating Factors(Medicinal Chemistry,Chemical)
- PREPARATION OF (22S)- AND (22r)-24-HOMO-26,26,26,27,27,27-HEXAFLUORO-1,22,25-TRIHYDROXY-24-YNE-VITAMIN D_3
- Studies on Organic Fluorine COmpounds. IL. The Ene Reaction of Trifluoroacetone
- Studies on Organic Fluorine Compounds. XLIII. The Ene Reaction of Hexafluoroacetone
- Studies on Organic Fluorine Compounds. XLI. The Friedel-Crafts Reaction of Trifluoropropene
- Synthesis and Biological Activity of 1α-Fluoro-25-hydroxyvitamin D_3
- Studies on Organic Fluorind Compounds. LII : Synthesis and Biological Activity of 26,26,26,27,27-Pentafluoro-1α-hydroxy-27-methoxyvitamin D_3
- 大腸がんとビタミンD : 含フッ素1,25-(OH)_2D_3アナログDD-003のin vivo実験
- Studies on the Reaction of Heterocyclic Compounds. XV. N-Alkylation of 1,2,3,4-Tetrahydro-5-methyl-1,6-naphthyridine
- Studies on the Reactions of Heterocyclic Compounds. XIV. 1,3-dipolar Cycloaddition of Some Isoquinolinium Ylides with Methyl Propiolate
- STEREOSELECTIVE SYNTHESIS OF TRIFLUOROMETHYLATED OLEFIN AND DIENE
- Studies on Organic Fluorine Compounds. XLVII. Synthesis of Trifluoromethylated Sugars through the Aldol Reaction of 2-Trimethylsilyloxy-4-trifluoromethylfuran
- フッ素と薬学
- Studies on Organic Fluorine Compounds. VII. Trifluoromethylation of Aromatic Compounds
- Studies on Organic Fluorine Compounds. XLVI. Synthesis of 4-Trifluoromethyl-2 (5H)-furanone and 4-Trifluoromethyl-N-substituted Dihydropyrrol-2-ones
- SYNTHESIS OF TRIFLUOROMETHYLATED LACTONE AND EPOXIDE
- RADICAL CYCLIZATIONS TO FLUOROOLEFINS
- 有機フッ素化合物の合成と反応 : 30年の研究を振り返って
- Preparation and Biological Activity of 24-Epi-26,26,26,27,27,27-hexafluoro-1α, 25-dihydroxyvitamin D_2
- TRIFLUOROMETHYLATION OF CHIRAL ALDEHYDE AND SYNTHESIS OF 6-DEOXY-6,6,6-TRIFLUOROHEXOSES
- Synthesis of Fluorinated Retinal : A C_6-C_7 s-trans Fixed Retinal Containing a Trifluoromethyl Group at the Terminal Position of the Conjugated System
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- オクテット
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- ENANTIOSELECTIVE REDUCTION OF FLUOROALKYL ALKYNYL KETONES : ENORMOUS ELECTRONIC EFFECT OF THE TRIFLUOROMETHYL GROUP(Communications to the Editor)
- SYNTHESIS OF 5-FLUOROARACHIDONIC ACID AND ITS BIOTRANSFORMATION TO 5-FLUORO-12-HYDROXYEICOSATETRAENOIC ACID(Communications to the Editor)
- KINETIC RESOLUTION OP FLUORQALKYL (E)-VINYL CARBINOL DERIVATIVES BY ASYMMETRIC EPOXIDAT1QN WITH TITANIUM-TARTRATE CATALYSTS(Communications to the Editor)
- Studies on Organic Fluorine Compounds. L. Synthesis and Biological Activity of 2α-Fluorovitamin D_3
- Trifluoromethylation with Bromotrifluoromethane
- Studies on Organic Fluorine Compounds. XLIV. The Diels-Alder Reaction of Trifluoromethylated Cyclopropenyl Ketone and Its Imine
- フッ素薬学のこれから
- γ, γ-ジアルコキシアリルジルコニウム種を用いた炭素-炭素結合形成反応の開発
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- 雑感
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- 奨励賞受賞 伊藤久央氏の業績
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- 光学活性アトロプ異性アニリド誘導体の合成と不斉反応への応用
- 学術貢献賞受賞伊関克彦氏の業績
- ハロ環化中間体形成を活性化手法として用いる有機合成反応の開発
- フッ素置換基を有するラジカル環化系の反応
- ヨードカルボ環化反応
- ジルコノセン錯体を用いた炭素-炭素結合形成反応の新展開
- Simmons-Smith Reactions of Fluoroallyl Alcohol Derivatives
- 小林義郎先生紫綬褒章受賞
- Studies on the Organic Fluorine Compounds. XXIV. Photochemical Trifluoromethylation of Aromatic Compounds
- Studies on Organic Fluorine Compounds. XX. Synthesis and Reactions of a Substituted Dewar Pyridine
- Studies on Organic Fluorine Compounds. XIX. Synthesis and Reactions of"Dewar"Thiophene
- Studies on Organic Fluorine Compounds. XVI. : Stereochemistry in Fluorination of Sterols with Phenylfluorophosphoranes
- Studies on Organic Fluorine Compounds. XI. Reaction of Arylfluorophosphoranes with Alcohols
- Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes
- 複素5員環化合物の原子価結合異性体
- 有機化合物へのフッ素導入法
- 含フッ素生理活性物質の合成 (「医薬品開発をめぐる生理活性物質の合成」特集号)
- ペルフルオロアルキル芳香族の化学 (新しいフッ素化学)
- CF3基で安定化された芳香族化合物の原子価結合異性体の化学
- CF3基を有するヘテロ環の化学 (ヘテロ環の化学)
- Studies on Organic Fluorine Compounds. XXII. Synthesis and Reactions of (Trifluoromethyl) benzofurans
- 有機フッ素化学とライフサイエンス
- Studies on Organic Fluorine Compounds. XVIII. On the Mechanism of the Conversion of Trifluoromethyl Group to Amino Group on a Quinoline Ring
- Studies on Organic Fluorine Compounds. XVII. Reaction of Benzotrifluoride Derivatives with Sodium Amide
- Studies on the Reactions of Heterocyclic Compounds. XIII. Basicity of 1,6-Naphthyridine and Its N-Oxides : Correlation to Peracid Oxidation
- Studies on the Reaction of Heterocyclic Compounds. XII. N-Oxidation of Diazabenzene and Diazanaphthalene
- Studies on the Reactions of Heterocyclic Compounds. X. 1,3-Dipolar Cycloaddition Reaction of Isoquinolinium Ylides and Dicyanoacetylene
- STEREOSELECTIVE SYNTHESIS OF gem-BISTRIFLUOROMETHYLCYCLOPROPANE DERIVATIVES
- Studies on Organic Fluorine Compounds. XXXI. Oxidative Coupling of Ketone Enolates and Trimethylsilyl Enol Ethers by Means of Cu(OTf)_2
- Studies on Organic Fluorine Compounds. XL. Ring-Opening Reactions of gem-Difluorocyclopropyl Carbinols
- Studies on Organic Fluorine Compounds. XXXIX. Studies on Steroids. LXXIX. Synthesis of 1α, 25-Dihydroxy-26,26,26,27,27,27-hexafluorovitamin D_3
- Studies on the Reactions of Heterocyclic Compounds. XI. Methylation of Heteroaromatic N-Oxides
- Oxidative Cyanation of Aromatic Amine Oxides
- Studies on the Reactions of Heterocyclic Compounds. III. Cyanation of 1,6-Naphthyridine N-Oxides
- Studies on the Reactions of Heterocyclic Compounds. I. Syntheses and Some Reactions of 1,6-Naphthyridine N-Oxides
- Synthesis and Biological Activities of Novel Antiallergic Agents with 5-Lipoxygenase Inhibiting Action.
- Synthesis of Benzimidazole Derivatives as Antiallergic Agents with 5-Lipoxygenase Inhibiting Action
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- 含フッ素生理活性物質の合成
- CF3基で安定化された芳香族化合物の原子価結合異性体の化学
- ジルコノセン錯体を用いた炭素一炭素結合形成反応の新展開
- Studies on Organic Fluorine Compounds. X. Reaction of Trifluoromethyl Group in Heterocycles with Sodium Amide
- 1-PHENYLSULFONYL-3,3,3-TRIFLUOROPROPENE I : THE MICHAEL-TYPE ADDITION REACTION
- 有機フッ素化合物と生理活性
- gem-ジフルオロシクロプロパン誘導体の開環反応を用いるフルオロオフレィン類の合成 (フッ素の化学とその応用)
- ビタミンD3のフッ素による化学修飾
- Studies on the Reactions of Heterocyclic Compounds. II. Syntheses and Some Reactions of 1,6-Phenanthroline N-Oxides
- オクテット
- 有機フッ素化合物の合成と反応
- 有功会員 溝口歌子先生を悼む
- 名誉会員R.B.Woodward教授を悼む
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- Studies on Organic Fluorine Compounds. VIII. Alcoholysis of (Trifluoromethyl) quinolines
- Studies on Organic Fluorine Compounds. VI. Preparations and Reactions of (Trifluoromethyl) quinoline N-Oxides
- Studies on Organic Fluorine Compounds. XXX. Ring Opening Reaction of Acetoxydifluorocyclopropanes with Various Nucleophiles
- Studies on Organic Flourine Compounds. V. Preparations and Reactions of N-Oxides of Trifluoromethylated Pyridines
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