Studies on Organic Fluorine Compounds. XL. Ring-Opening Reactions of gem-Difluorocyclopropyl Carbinols
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概要
- 論文の詳細を見る
Three types of ring-opening reactions of gem-difluorocyclopropyl carbinols are described ; 1) reaction with hydrobromic acid, 2) reaction with acetic acid in the presence of p-toluenesulfonic acid, and 3) rearrangement through a mesylate. Ring-opening reactions of 1a, d, e having an electron-donating substituent at C_3 were found to give β, β-difluorohomoallyl derivatives derived from C_1-C_3 bond scission. On the other hand, reactions of 1b, c having hydrogen atoms or a methyl group at C_3 were not selective or afforded α, α-difluorohomoallyl derivatives (C_1-C_2 bond scission) preferentially.
- 公益社団法人日本薬学会の論文
- 1983-08-25
著者
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田口 武夫
東京薬科大学薬学部
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田口 武夫
Tokyo College of Pharmacy
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小林 義郎
東京薬科大学薬学部
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森川 勉
Tokyo College of Pharmacy
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森川 勉
東京薬科大学薬学部
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