Antioxidant Activities of Chitobiose and Chitotriose(Miscellaneous)
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概要
- 論文の詳細を見る
Chitooligosaccharides, the oligomers made up of μ-1,4-linked D-glucosamine, are obtained by partial hydrolysis of chitosan, a deacetylation product of chitin. The antioxidant activity of various chitooligosaccharides was tested in vitro with aminoguanidine, pyridoxamine, and Trolox as reference compounds. Hydroxylation of benzoate to salicylate by H_2O_2 in the presence of Cu^<2+> was effectively inhibited by chitobiose, chitotriose, aminoguanidine, pyridoxamine, and Trolox (their IC_<50> values=18, 80, 85, 10, and 95μM, respectively), whereas glucosamine and N-acetylchito-oligosaccharides (di-N-acetylchitobiose and tri-7V-acetylchitotriose) did not show any inhibitory activity. Chitobiose and chitotriose were more potent than the 3 reference compounds in scavenging hydroxyl radicals produced by photolysis of zinc oxide: IC_<50> values of the 2 oligomers were 30 and 55 μM, respectively. Such a scavenging activity of these 2 chitooligomers was also shown by the use of another system, a mixture of Fe^<3+>/EDTA/ascorbate/H_2O_2, for producing hydroxyl radicals. Only chitobiose and Trolox, of the 10 compounds tested, had the ability to scavenge superoxide radicals generated by a non-enzymatic system using phenazine methosulfate and NADH. Taken together with our unpublished observation that chitobiose and chitotriose are appreciably absorbed from the intestine of rats, the present results suggest that these 2 chitooligosaccharides would act as effective antioxidants in vivo when orally ingested.
- 社団法人日本薬学会の論文
- 2003-09-01
著者
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田口 武夫
東京薬科大学薬学部
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Wang Min-wei
中華人民共和国
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Wang Min-wei
Department Of Pharmacology Shenyang Pharmaceutical University School Of Pharmacy
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TAGUCHI Tadao
Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University
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SAKAI Kazuo
Yaizu Suisan Kagaku Industry Co.
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MIWA Ichitomo
Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University
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CHEN An-Shu
Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University
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KIKUCHI Kazuaki
Yaizu Suisankagaku Industry Co.
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Chen An-shu
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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Taguchi T
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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Taguchi Tadao
Department Of Clinical Biochemistry Faculty Of Pharmacy Meijo University
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Sakai K
Yaizu Suisan Kagaku Industry Co.
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Miwa Ichitomo
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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Wang Min-wei
Department Of Pharmacology Shen Yang Pharmaceutic University
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MIWA ICHITOMO
Department of Clinical Biochemistry, Faculty of Pharmaceutical Science, Meijo University
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