Vasodilatation Produced by Orientin and Its Mechanism Study(Pharmacology)

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概要

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• In this paper we investigated the vascular activity and possible mechanism of Orientin, from bamboo leaves (Phyllostachys nigra), in isolated thoracic aortic rings from New Zealand rabbit. Among the four compounds, studied, only Orientin relaxed phenylephrine-induced contractions with an IC_<50> value of 2.28 μM in the endothelium intact and with an IC_<50> value around 7.27 μM in the endothelium removed aortic rings. The vasorelaxant effect of Orientin on endothelium-intact thoracic aortic rings was attenuated by the nitric oxide (NO) synthase inhibitor N^G-nitro-L-arginine methyl ester, but not by indomethacin (a cyclooxygenase inhibitor), tetraethylammonium chloride (K^+ channels inhibitor) or propranolol (β-receptor inhibitor). Furthermore, Orientin inhibited norepinephrine (NE), CaCl_2 and KCl-induced vasoconstriction concentration dependently in a non-competitive manner, and also reduced both the initial fast release and the sustained phases of phenylephrine-induced contractions. Orientin can stimulate NO production from endothelial cells. Orientin also increased cyclic guanosine 3, 5-cyclic monophosphate (cGMP) levels without changes in adenosine-3', 5'-cyclic phosphoric acid (cAMP) in rabbit aorta. The results showed that Orientin relaxed thoracic aortic rings by the nitric oxide-cGMP pathway, and in the vascular smooth muscle inhibited the contraction induced by the activation of receptor-operating and voltage-dependent Ca^<2+> channels. Cyclooxygenase pathway, potassium channels, β-receptors and cAMP pathway, on the other hand, had no apparent roles. The inhibition of both intracellular Ca^<2+> release and extracellular Ca^<2+> influx may be one of the main vasorelaxant mechanisms of Orientin.

• 公益社団法人日本薬学会の論文
• 2005-01-01

著者

• Wang Min-wei

  Department Of Pharmacology Shenyang Pharmaceutical University School Of Pharmacy

• ZHANG Ying

  College of Animal science and Veterinary Medicine, Jinlin University

• Li Shao-peng

  Department Of Brain Neurosurgery China Medical University

• Zhang Ying

  College Of Animal Science And Veterinary Medicine Jinlin University

• Fu Xiao-chun

  Department Of Pharmacology Shenyang Pharmaceutical University

• Zhang Y

  College Of Biosystem Engineering And Food Science Zhejiang University

• WANG Huai-Liang

  Department of Clinical Pharmacology, China Medical University

• Wang Huai-liang

  Department Of Clinical Pharmacology China Medical University

• Wang Min-wei

  Department Of Pharmacology Shenyang Pharmaceutical University

• Wang Min-wei

  Department Of Pharmacology Shen Yang Pharmaceutic University

• Zhang Ying

  College Of Animal Science And Technology Shanxi Agriculture University

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