Effect of Chitobiose and Chitotriose on Carbon Tetrachloride-Induced Acute Hepatotoxicity in Rats(Pharmacology)

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概要

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• The purpose of the present study was to examine whether chitobiose and chitotriose can protect rats from CCl_4-induced hepatic toxicity when given orally. We studied the effects of the 2 chitooligosaccharides given orally to rats on the acute hepatotoxicity induced by CCl_4-dependent lipid peroxidation. The increase in the sum of malondialdehyde and 4-hydroxy-2-alkenals, a marker of lipid peroxidation, in both plasma and liver of CCl_4-treated rats was suppressed by oral administration of chitobiose or chitotriose. The elevation in the levels of plasma aspartate transaminase and alanine transaminase activities, markers of hepatic injury, induced by CCl_4 intoxication was also counteracted by oral administration of either chitooligosaccharide. The results indicate that chitobiose and chitotriose have the ability to exert a protective action against CCl_4-induced acute hepatoxicity, probably by their antioxidant activity.

• 社団法人日本薬学会の論文
• 2005-10-01

著者

• 田口 武夫

  東京薬科大学薬学部

• WANG Min

  Department of Entomology, College of Natural Resources & Environment, South China Agricultural Unive

• Wang Min-wei

  中華人民共和国

• Wang Min-wei

  Department Of Pharmacology Shenyang Pharmaceutical University School Of Pharmacy

• CHEN An

  Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University

• TAGUCHI Tadao

  Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University

• SAKAI Kazuo

  Yaizu Suisan Kagaku Industry Co.

• MATAHIRA Yoshiharu

  Yaizu Suisan Kagaku Industry Co.

• MIWA Ichitomo

  Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University

• CHEN An-Shu

  Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University

• Chen An-shu

  Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University

• Taguchi T

  Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University

• Taguchi Tadao

  Department Of Clinical Biochemistry Faculty Of Pharmacy Meijo University

• Wang Min

  Department Of Chemistry Lanzhou University

• Sakai K

  Yaizu Suisan Kagaku Industry Co.

• Misawa Yoshitomo

  Yaizu Suisankagaku Industry Co. Ltd

• Miwa Ichitomo

  Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University

• Wang Min

  Department Of Applied Chemistry Harbin Institute Of Technology

• Wang Min

  Department Of Applied Chemistry China Agricultural University

• MIWA ICHITOMO

  Department of Clinical Biochemistry, Faculty of Pharmaceutical Science, Meijo University

• WANG Min

  Department of Anatomy and Embryology, Ehime University Graduate School of Medicine

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