Effects of α-D-Mannose and Equilibrated D-Mannose on Insulin Release
スポンサーリンク
概要
- 論文の詳細を見る
The effects on insulin release of α-D-mannose and equilibrated D-mannose were studied in the isolated perfused rat pancreas. Although phosphomannose isomerase, in contrast to phosphoglucose isomerase, is stereospecific for β-D-mannose-6-phosphate, the α anomer of D-mannose (2mg/m<I>l</I>) was significantly more effective than equilibrated D-mannose in stimulating insulin release. The finding does not seem to accord with the view that the signal for hexose-induced insulin release arises from the glycolytic pathway, and suggests the existence of the stereospecific glucoreceptor (s) on the pancreatic B-cell membrane.
- 社団法人 日本内分泌学会の論文
著者
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Miwa Ichitomo
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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NIKI ATSUSHI
Department of Internal Medicine, Scbool of Dentistry, Aichigakuin University
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NIKI HATSUMI
Department of Internal Medicine, Scbool of Dentistry, Aichigakuin University
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MIWA ICHITOMO
Department of Clinical Biochemistry, Faculty of Pharmaceutical Science, Meijo University
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