Acceleration of Glycolysis in Erythrocytes by the Antidiabetic Agent M16209

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概要

• 論文の詳細を見る

• The effects of M16209 (1-(3-bromobenzofuran-2-ylsulfonyl)hydantoin), an antidiabetic agent and aldose reductase inhibitor, on glycolysis were studied in rat and human erythrocytes in vitro. M16209 increased lactate production from glucose when incubated with rat and human erythrocytes, and also increased glucose consumption in rat erythrocytes. The rates of production of lactate in rat erythrocytes treated with M16209 at 10,25 and 50 μM were 113,118 and 123%, respectively, of those in vehicle treated cells. Sorbinil (aldose reductase inhibitor), tolbutamide (sulfonylurea), and buformine (biguanide) did not increase lactate production in rat erythrocytes when tested at 50 μM. On the other hand, M16209 did not affect lactate production from D-glyceraldehyde in rat erythrocytes. At 100 μM the agent decreased both glucose-6-phosphate and fructose-6-phosphate in rat erythrocytes, and increased fructose-1,6-bisphosphate; at 10 μM it also increased 6-phosphofructokinase activity in rat hemolysates. These findings suggest that M16209 accelerates glycolysis in erythrocytes via activation of 6-phosphofructokinase.

• 社団法人日本薬学会の論文
• 1996-06-15

著者

• Okuda Jun

  Department of Cardiology, Yokohama City University Medical Center

• MIWA Ichitomo

  Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University

• Kato Katsuaki

  Department Of Pharmacology Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

• Kato Katsuaki

  Department Of Materials Science And Chemical Engineering Faculty Of Engineering Shizuoka University

• Hashimoto Koji

  Department Of Dermatology Ehime University Graduate School Of Medicine

• Ohta Masahiko

  Department Of Pharmacology Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

• Ohta Masahiko

  Department Of Civil Engineering School Of Engineering

• Ohta Masahiko

  Research Center Mochida Pharmaceutical Co.

• MURAKAMI Nobuya

  Department of Pharmacology, Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,

• MIZOTA Masahiro

  Department of Pharmacology, Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,

• Okuda J

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Murakami Nobuya

  Department Of Pharmacology Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

• Mizota M

  Department Of Pharmacology Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

• Miwa I

  Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University

• Miwa Ichitomo

  Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University

• Ohta Masahiko

  Department Of Chemistry And Biochemistry Graduate School Of Engineering Kyushu University

• Hashimoto Koji

  Department Of Pharmacology Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

• Hashimoto Koji

  Department Of Chemistry Faculty Of Science Kanazawa University

• MIWA ICHITOMO

  Department of Clinical Biochemistry, Faculty of Pharmaceutical Science, Meijo University

• HASHIMOTO KOJI

  Department of Cardiovascular and Digestive Surgery, Shimane University School of Medicine

• OKUDA JUN

  Department of Biochemistry, School of Medicine, Nagoya University

• MIZOTA Masahiro

  Department of Pharmacology, Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd

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