IM-2,a Butyrolactone Autoregulator, Induces Production of Several Nucleoside Antibiotics in Streptomyces sp. FRI-5
スポンサーリンク
概要
- 論文の詳細を見る
IM-2 is one of the butyrolactone autoregulators of Streptomyces, which triggers production of a blue pigment in Streptomyces sp. FRI-5 at a concentration of 0.6 ng/ml. In the absence of IM-2,Streptomyces sp. FRI-5 was found to produce D-cycloserine. However, the addition of IM-2 at 5-h cultivation stopped both growth and D-cycloserine production, and instead induced production of several different antibiotics. The IM-2-induced antibiotics were isolated from the culture broth, and assigned as the nucleoside antibiotics, showdomycin and minimycin. Therefore, IM-2 was concluded to be a global regulator of secondary metabolism, which not only induced the production of nucleoside antibiotics but also suppressed D-cycloserine production.
- 社団法人日本生物工学会の論文
- 1992-06-25
著者
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作田 庄平
東京大学大学院農学生命科学研究科応用生命化学専攻
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Yamada Yasuhiro
Department Of Biotechnology Osaka University
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Sakuda S
Department Of Applied Biological Chemistry The University Of Tokyo
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Yamada Y
Department Of Biotechnology Faculty Of Engineering Osaka University
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SAKUDA Shohei
Department of Applied Biological Chemistry, University of Tokyo
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Nihira Takuya
Department of Fermentation Technology, Faculty of Engineering, Osaka University
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Hashimoto Koji
Department Of Dermatology Ehime University Graduate School Of Medicine
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Sakuda Shohei
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Nihira Takuya
Department Of Biotechnology Osaka University
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Nihira Takuya
Department Of Biotechnology Faculty Of Engineering Osaka University
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Nakamura Takefumi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Nihira T
International Center For Biotechnology Osaka University
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作田 庄平
東大 大学院
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Hashimoto K
Department Of Cardiovascular And Digestive Surgery Shimane University School Of Medicine
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Yamada Yasuhiro
Department Of Agricultural Chemistry Faculty Of Agriculture University Of Tokyo
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Hashimoto Koji
Department Of Chemistry Faculty Of Science Kanazawa University
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Nihira T
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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HASHIMOTO KOJI
Department of Cardiovascular and Digestive Surgery, Shimane University School of Medicine
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HASHIMOTO Koji
Department of Physics, Kyoto University
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SAKUDA Shohei
Department of Agricultural Chemistry, The University of Tokyo
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