Enhanced therapeutic effect on murine melanoma and angiosarcoma cells by boron neutron capture therapy using a boronated metalloporphyrin.

スポンサーリンク

概要

• 論文の詳細を見る

• We have already achieved successful treatment of several human patients with malignant melanoma by boron neutron capture therapy (BNCT) using 10B1-paraboronophenylalanine (10B1-BPA). In this communication we used a new compound, a manganese boronated protoporphyrin (Mn-10BOPP), and compared it to 10B1-BPA.HCl with respect to uptake in murine melanoma and angiosarcoma cells as well as to their respective cell killing effects using BNCT. Mn-10BOPP was found to be 3 to 10 times more effectively taken up by melanoma cells and angiosarcoma cells than 10B1-BPA.HCl when the content of 10B was measured by the new method, inductively coupled plasma-mass spectrometry (ICP-MS). In addition, melanoma cells and angiosarcoma cells preincubated with Mn-10BOPP were 15 to 20 times more efficiently killed by BNCT than cells preincubated with 10B1-BPA.HCl. These results suggest that Mn-10BOPP is a suitable compound for BNCT of not only malignant melanoma but also angiosarcoma.

• 神戸大学の論文

著者

• Yamada Y

  Department Of Oncologic Pathology Kanazawa Medical University

• Toda K

  Department Of Applied Chemistry And Biotechnology Niigata Institute Of Technology

• Yamada Y

  Department Of Biotechnology Faculty Of Engineering Osaka University

• Kahl Sb

  Department Of Dermatology Kobe University School Of Medicine

• Ichihashi M

  Department of Dermatology, Kobe University School of Medicine

• Ichihashi M

  Department Of Dermatology Kobe University School Of Medicine

• Yamada Y

  Department Of Applied Chemistry Faculty Of Engineering Kanagawa University

関連論文

• Lack of Enhancing Effect of Lauric Acid on the Development of Aberrant Crypt Foci in Male ICR Mice Treated with Azoxymethane and Dextran Sodium Sulfate
• Enhancement of Acetic Acid Production in a High Cell-Density Culture of Acetobacter aceti
• Effects of Dissolved Oxygen and Acetic Acid Concentrations on Acetic Acid Production in Continuous Culture of Acetobacter aceti
• Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1, 2-dimethylhydrazine dihydrochloride
• Tumor formation is correlated with expression of β-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice
• A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
• Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide
• Carcinoid tumor in the female urethral orifice : Rare case report and a review of the literature
• Induction of Apoptosis by Sulindac in Azoxymethane-induced Possible Colonic Premaligmant Lesions in Rats
• Chemopreventive Effects of a Flavonoid Antioxidant Silymarin on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Urinary Bladder Carcinogenesis in Male ICR Mice
• Dietary Prevention of Azoxymethane-Induced Colon Carcinogenesis with Rice-Germ in F344 Rats.
• β-Catenin (Ctnnb1) Gene Mutations in Diethylnitrosamine (DEN)-induced Liver Tumors in Male F344 Rats
• Suppression of Occurrence and Advancement of β-Catenin-accumulated Crypts, Possible Premalignant Lesions of Colon Cancer, by Selective Cyclooxygenase-2 Inhibitor, Celecoxib
• Effects of Nutrient-Poor and Anaerobic Conditions on Maintenance of R100-1 and RSF2124 Plasmids in Model Populations of Escherichia coli
• Stability of Plasmid-Bearing Microorganisms in Batch and Continuous Cultures
• Modifying Effects of Ferulic Acid on Azoxymethane-Induced Colon Carcinogenesis in F344 Rats.
• SUPPRESSIVE EFFECTS OF CHLOROGENIC ACID ON N-METHYL-N-NITROSOUREA-INDUCED GLANDULAR STOMACH CARCINOGENESIS IN MALE F344 RATS
• Inhibitory Effects of Nabumetone, a Cyclooxygenase-2 Inhibitor, and Esculetin, a Lipoxygenase Inhibitor, on N-Methyl-N-nitrosourea-induced Mammary Carcinogenesis in Rats
• Inhibitory Effect of NS-398, a Selective Cyclooxygenase-2 Inhibitor, on Azoxymethane-induced Aberrant Crypt Foci in Colon Carcinogenesis of F344 Rats
• Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats
• Absolute Configuration of Allosamizoline, an Aminocyclitol Derivative of the Chitinase Inhibitor Allosamidin(Organic Chemistry)
• PD33 BIOSYNTHESIS OF MACROLIDE ANTIBIOTIC PATULOLIDES BY Penicillium urticae S11R59 : IDENTIFICATION OF THE ORIGIN OF CARBON ATOMS BY ^C NMR SPECTROSCOPY
• PC88 THE STRUCTURES OF INDUCING FACTORS FOR VIRGINIAMYCIN PRODUCTION IN Streptomyces virginiae
• Chemopreventive Effect of N-(2-Cyclohexyloxy-4-nitrophenyl)methane Sulfonamide (NS-398), a Selective Cyclooxygenase-2 Inhibitor, in Rat Colon Carcinogenesis Induced by Azoxymethane
• Nucleotide Sequences of Genes Encoding Allosamidin-sensitive and -insensitive Chitinases Produced by Allosamidin-producing Streptomyces(Biochemistry & Molecular Biology)
• Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer
• Malignant phyllodes tumor of the prostate: Retrospective review of specimens obtained by sequential transurethral resection
• Structure of a Novel Disulfide of 2-(N-Acetylcysteinyl)amido-2-deoxy-α-D-glucopyran-osyl-myo-inositol Produced by Streptomyces sp.
• Purification of Allosamidin-sensitive and -insensitive Chitinases Produced by Allosamidin-producing Streptomyces
• New Inducing Factors for Virginiamycin Production from Streptomyces antibioticus
• IM-2,a Butyrolactone Autoregulator, Induces Production of Several Nucleoside Antibiotics in Streptomyces sp. FRI-5
• 517 Oxidases Involved in the Biosynthesis of Macrolide Antibiotics Patulolides from Penicillium urticae S11R59
• Accumulation of S-2-Hydroxyethyl Derivatives of L-Cysteine and L-Homocysteine by a Methionine Auxotroph of Escherichia coli with the Addition of 2-Mercaptoethanol to the Culture(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Accumulation of _L-Cystathionine by an Escherichia coli Mutant Deficient in Cystathionine Beta-Lyase
• Promotion of Antibiotic Production by High Ethanol, High NaCl Concentration, or Heat Shock in Pseudomonas fluorescens S272
• Correlation between Autoinducers and Rhomnolipids Production by Pseudomonas aeruginosa IFO 3924
• Preparation of a Demethylallosamidin Isomer Having an N,N'-Diacetylchitobiosyl Moiety and Its Potent Inhibition against Yeast Chitinase
• Synthesis of a New Allosamidin Analog, N,N'-Diacetyl-β-Chitobiosyl Allosamizoline, and Its Inhibitory Activity against Some Chitinases
• Distribution of Virginiae Butanolides and IM-2 in the Genus Streptomyces
• Ioslation and Structure of a New Butyrolactone Autoregulator from Streptomyces sp. FRI-5
• Glutathione as an Essential Factor for Chaperon-Mediated Activation of Lactonizing Lipase(LipL)from Pseudomonas sp.109
• Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus
• A Modified Model for Non-Newtonian Viscosity behavior of Aureobasidium pullulans Culture Fluid
• Characteristic Behavior of Viscosity and Viscoelasticity of Aureobasidium pullulans Culture Fluid
• Fluid Viscosity of Aureobasidium pullulans Cultures Obtained at Two Different Initial pH Values
• Cell Concentration Dependence of Dynamic Viscoelasticity of Escherichia coli Culture Suspensions
• Cellulose Production by Acetic Acid-Resistant Acetobacter xylinum
• Transformation of Acetobacter polyoxogenes with Plasmid DNA by Electroporation
• The aarC Gene Responsible for Acetic Acid Assimilation Confers Acetic Acid Resistance on Acetobacter aceti
• Spheroplast Fusion of Acetobacter aceti and Its Application to the Breeding of Strains for Vinegar Production(Microbiology & Fermentation Industry)
• Enhanced therapeutic effect on murine melanoma and angiosarcoma cells by boron neutron capture therapy using a boronated metalloporphyrin.
• Synthesis of Polymers in Aqueous Solutions. Synthesis of Polyesters by Reactions of Dicarboxylic Acids with Alkylene Dihalides Using 1,8-Diazabicyclo[5.4.0]undec-7-ene in Aqueous Solutions
• 2.CARDIO VASCULAR TEST OF ATHLETES
• Genetic ablation of a candidate tumor suppressor gene, Rest, does not promote mouse colon carcinogenesis
• PCNA expression and nucleolar organizer regions in malignant melanoma and nevus cell nevus.

もっと見る 閉じる

スポンサーリンク