SUPPRESSIVE EFFECTS OF CHLOROGENIC ACID ON N-METHYL-N-NITROSOUREA-INDUCED GLANDULAR STOMACH CARCINOGENESIS IN MALE F344 RATS

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概要

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• The modifying effects of chlorogenic acid (CA) on N-methyl-N-nitrosourea (MNU)-induced glandular stomach carcinogenesis were investigated in five groups of male F344 rats. Rats in Groups 1 through 3 were given MNU in drinking water at a concentration of 400 ppm for 12 weeks. Animals of Group 1 were then kept on the basal diet alone, and those of Group 2 or 3 were fed a diet containing 500 or 250 ppm CA for a subsequent 22 weeks. Group 4 was exposed to CA alone through the experimental period (36 weeks), and Group 5 was given the basal diet continuously and treated as a control. At the end of the experiment, the incidence of glandular stomach carcinoma of Group 3 was significantly smaller than that of Group 1 (p<0.03). The incidence of adenomatous hyperplasia of Group 2 was also significantly lower than that of Group 1 (p<0.02). In addition, the proliferating cell nuclear antigen (PCNA) labeling index of the epithelial cells from the non-neoplastic mucosa in rats of Group 2 or 3 was significantly smaller than that of Group 1 (p<0.0001). These results suggest that CA has a chemopreventive effect on MNU-induced rat glandular stomach carcinogenesis by exposure during the post-initiation phase, and CA may be a promising agent for prevention of human stomach cancer.

• 日本トキシコロジー学会の論文
• 1999-12-20

著者

• Yamada Yasuhiro

  Department Of Biotechnology Osaka University

• Mori Hideki

  Department of Biological Science, Graduate School of Science, Osaka Prefecture University

• Saio Masanao

  高山赤十字病院 循環器内科

• Yoshimi N

  Department Of Pathology Faculty Of Medicine University Of The Ryukyus

• Yoshimi Naoki

  琉球大学 医学部腫瘍病理学

• SUZUI Masumi

  Tumor Pathology, University of Ryukyus Faculty of Medicine

• HARA Akira

  Department of Pathology, Gifu University School of Medicine

• YOSHIMI Naoki

  Department of Pathology,Faculty of Medicine,University of the Ryukyus

• Shimazaki M

  Department Of Internal Medicine Gifu University School Of Medicine

• Shimazaki Makoto

  岐阜大学 1内

• MATSUNAGA Kengo

  Departments of Pathology, Gifu University School of Medicine

• KAWABATA Kunihiro

  Departments of Pathology, Gifu University School of Medicine

• Yamada Y

  Department Of Oncologic Pathology Kanazawa Medical University

• Moriwaki Hisataka

  岐阜大学 医学部内科学

• Moriwaki Hisataka

  がん･感染症センター都立駒込病院 肝臓内科

• Kawabata Kunihiro

  First Department Of Pathology Gifu University School Of Medicine

• Kawabata Kunihiro

  Department Of Pathology Gifu University School Of Medicine

• Matsunaga Kengo

  First Department Of Pathology Gifu University School Of Medicine

• Shiraki Makoto

  岐阜大学 医学部内科学

• Suzui Masumi

  Internal Medicine Gifu University School Of Medecine

• KATAOKA Keiko

  Department of Bacteriology, School of Medicine, The University of Tokushima

• Suzui Masumi

  琉球大学 医学部腫瘍病理学

• Suzui Masumi

  琉球大学 医学部病理学

• Kataoka K

  Univ. Tokushima Tokushima Jpn

• SHIMIZU Masahito

  Department of Pathology, Gifu University School of Medicine

• MORIWAKI Hisataka

  1st Department of Internal Medicine, Gifu University School of Medicine

• Moriwaki Hisataka

  1st Department Of Internal Medicine Gifu University School Of Medicine

• Suzui Masumi

  Tumor Pathology University Of The Ryukyus Faculty Of Medicine

• Shimizu Masahito

  Department Of Medicine Gifu University Graduate School Of Medicine

• Hara Akira

  Lab. Of Biochemistry Gifu Pharmaceutical Univ.

• Yasui Yumiko

  Department Of Oncologic Pathology Kanazawa Medical University

• Hara Akira

  Laboratory Of Biochemistry Gifu Pharmaceutical University

• Hara Akira

  Department Of Applied Biological Chemistry Faculty Of Agriculture Meijo University

• Mori Hideki

  Department Of Anatomy Okayama University Medical School

• Yoshimi Naoki

  Department Of Pathology Faculty Of Medicine University Of The Ryukyus

• Yamada Y

  Department Of Physics Faculty Of Science Kyoto University

• Kawabata Kunihiro

  Department Of Molecular Bacteriology Graduate School Of Medicine The University Of Tokushima

• Saio Masanao

  Department Of Medicine Gifu University Graduate School Of Medicine

• Yamada Yasuhiro

  Department Of Agricultural Chemistry Faculty Of Agriculture University Of Tokyo

• Kawabata Kunihiro

  Department Of Bacteriology School Of Medicine The University Of Tokushima

• Yoshimi Naoki

  School Of Pharmaceutical Sciences University Of Shizuoka

• Nakamura Yasushi

  School Of Pharmaceutical Sciences University Of Shizuoka

• Yoshimi Naoki

  Department of Pathology and Oncology, Graduate School of Medicine and Faculty of Medicine, University of the Ryukyus Faculty of Medicine, 207 Uehara, Nishihara-cho, Okinawa 903-0215, Japan

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