The Effects of a Novel Cyclohexane Dicarboximide Derivative, ST-6,on Hypoxia/Reoxygenation Injury in Perfused Rat Heart
スポンサーリンク
概要
- 論文の詳細を見る
The present study was undertaken to test if some cyclohexane dicarboximide derivatives may have a cardioprotective effect against hypoxia/reoxygenation injury. Isolated rat hearts were subjected to 20-min of hypoxiafollowed by 45-min reoxygenation, and their recovery of post-hypoxic cardiac contractile function was examined.Treatment with agents was carried out from 3 min after the onset of hypoxia to the end of hypoxia (17 min during hypoxia). Among the 17 compounds, 2-[4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]butyl]hexahydro-1H-isoindol-1,3(2H)-dione (ST-6) showed a significant enhancement of post-hypoxic contractile force. This was associated with attenuation of the releases of creatine kinase and purine nucleosides and based from the perfused heart. Hypoxia-induced increase in myocardial sodium and decrease in potassium ion content was suppressed by ST-6 treatment. The results suggest that ST-6 is capable of protecting the heart against hypoxia/reoxygenation injury possibly through a mechanism by which sodium overload during hypoxia is suppressed.
- 社団法人日本薬学会の論文
- 2000-06-01
著者
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Mori Hideki
Department of Biological Science, Graduate School of Science, Osaka Prefecture University
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TAKEO Satoshi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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TANONAKA Kouichi
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
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Takeo Satoshi
東京薬科大学 第一薬理学
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Kajiwara Hiroshi
Department of Pathology, Tokai University School of Medicine
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Takeo S
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Takeo Satoshi
Dep. Of Molecular And Cellular Pharmacology Tokyo Univ. Of Pharmacy And Life Sciences Jpn
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MIYAKE Keiko
Department of Pharmacology, Tokyo University of Pharmacy & Life Science
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ANTOKU Fujio
Research Center, Sumitomo Pharmaceutical Co., Ltd.,
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Takeo S
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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MIYAKE-TAKAGI Keiko
Department of Pharmacology, Tokyo University of Pharmacy Life Science
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Takagi Kaori
Department Of Pharmacology Tokyo University Of Pharmacy & Life Science
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Kajiwara Hiroshi
Department Of Pathology Tokai University School Of Medicine
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Tanonaka Kouichi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Kajiwara Hiroshi
Pharmacological Research Laboratories Drug Safety Testing Center Co. Ltd.
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Takeo Satoshi
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy & Life Science
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Antoku Fujio
Research Center Sumitomo Pharmaceutical Co. Ltd.
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Mori Hideki
Department Of Anatomy Okayama University Medical School
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Miyake Keiko
Department Of Pharmacology Tokyo University Of Pharmacy Life Science
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Miyake Keiko
Department Of Pharmacology Tokyo University Of Pharmacy & Life Science
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Tanonaka K
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Katakami Hideki
Departments Of Internal Medicine Miyazaki Medical College
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Katakami H
Department Of Pathology Tokai University School Of Medicine
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Mori Hideki
Department Of Pharmacology Faculty Of Pharmacy Fukuyama University
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Kajiwara Hiroshi
Department Of Neurosurgery Teikyo University Chiba Medical Center
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