SOME TOXIC PROPERTIES OF A CARCINOGENIC PYRROLIZIDINE ALKALOID, PETASITENINE

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概要

• 論文の詳細を見る

• Some toxic properties of petasitenine, a hepatocarcinogenic pyrrolizidine alkaloid, were confirmed in 3 parts of studies. Electron microscopic observation of rat liver on the stage of acute toxicity following administration of a toxic dose of petasitenine disclosed the distinctive changes i.e., nucleolar segregation, degradation of endoplasmic reticulum such as formation of concentric whorls in the liver cells. Biochemical test for the mitochondrial function in the isolated mitochondria from rat liver cells revealed on inhibitory effects of petasitenine in the respiratory system, indicating that minor changes of mitochondria on the pyrrolizidine alkaloid may be induced by some other indirect factor. Investigation for the effect of petasitenine on the cell cycle of the cultured cell line from the human carcinoma showed some inhibitory effects in the appearance of cells in S-phase or M-phase, suggesting a possibility that toxicity of petasitenine will be developed in the tissues other than the liver or in the species apart from rodents.

• 日本トキシコロジー学会の論文
• 1984-05-25

著者

• Mori Hideki

  Department of Biological Science, Graduate School of Science, Osaka Prefecture University

• Mori Hideki

  Department Of Pathology Gifu University School Of Medicine

• HIRONO Iwao

  Second Department of Pathology

• BUNAI Yasuo

  Department of Pathology, Gifu University School of Medicine

• HIRONO Iwao

  Department of Pathology, Fujita-Gakuen University School of Medicine

• Bunai Y

  Department Of Legal Medicine Gifu University School Of Medicine

• Bunai Y

  Department Of Pathology Gifu University School Of Medicine

• Bunai Yasuo

  Department Of Forensic Medicine Gifu University School Of Medicine

• Bunai Yasuo

  Department Of Pathology Gifu University School Of Medicine

• 武内 康雄

  岐阜大 医

• YAMADA Kiyoyuki

  Department of Chemistry, Faculty of Science, Nagoya University

• Mori Hideki

  Department Of Anatomy Okayama University Medical School

• OHBAYASHI Futoshi

  Department of Pathology, Gifu University School of Medicine

• Hirono I

  Department Of Carcinogenesis And Cancer Susceptibility Institute Of Medical Science University Of To

• Hirono Iwao

  Department Of Carcinogenesis And Cancer Susceptibility Institute Of Medical Science University Of To

• Kawai Kiyoshi

  Department Of Food Science And Technology Tokyo University Of Marine Science And Technology

• Kawai Kiyoshi

  Department Of Biofunctional Science And Technology Graduate School Of Biosphere Science Hiroshima Un

• Yamada Kiyoyuki

  Department Of Chemistry Faculty Of Science Nagoya University

• Hirono I

  Second Department Of Pathology

• Ohbayashi Futoshi

  Department Of Pathology Gifu University School Of Medicine

• Kawai Kiyoshi

  Department Of Biochemistry Gifu University School Of Medicine

• Hirono Iwao

  Department Of Carcinogenesis And Cancer Susceptibility Institute Of Medical Science University Of To

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