INFLUENCES OF LONG-TERM ADMINISTRATION OF 24R, 25-DIHYDROXYVITAMIN D_3, A VITAMIN D_3 DERIVATIVE, IN RATS
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概要
- 論文の詳細を見る
In order to examine the influences by long-term feeding of 24R, 25 dihydroxyvitamin D3_[24R, 25(OH)_2D_3], an active form of vitamin D, Wistar rats (14-week-old, male, 20 rats/group) were fed a powder diet containing 0 or 5 ppm 24R, 25(OH)_2D_3 for 57 weeks. Final body weights and total food consumption were comparable between the groups. Urinary calcium levels were significantly (p<0.05 or 0.01) increased by the administration of 24R, 25(OH)_2D_3 at weeks 3, 22 and 56, although the levels of serum calcium did not differ between the groups at the termination of week 57. In the 24R, 25(OH)_2D_3 group, weights of the adrenals and femurs were significantly (p<0.01) increased. Histopathologically this was found due to thickening of cortical bone in the femurs, and medullary hyperplasia and pheochromocytoma of the adrenals. Immunohistochemically, proliferating cell nuclear antigen (PCNA)-labeling indices for intact adrenal medulla, medullary hyperplasia and pheochromocytoma in the 24R, 25(OH)_2D_3 group were respectively 1.82±1.21, 5.88±4.13 and 16, all higher than that for the adrenal medulla in the control group (0.87±0.67). These results indicate that 24R, 25(OH)_2D_3 at a dose with which serum calcium is not chronically increased causes thickening of the cortex of the femur, and development of adrenal proliferative lesions, suggesting that rats may be too sensitive for results to be relevant to human risk assessment.
- 日本トキシコロジー学会の論文
- 1999-05-10
著者
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Hirose Masao
Division of Pathology, National Institute of Health Sciences
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Nishikawa Akiyoshi
Division of Pathology, National Institute of Health Sciences
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Mori Hideki
Department of Biological Science, Graduate School of Science, Osaka Prefecture University
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FURUKAWA Fumio
Division of Pathology, National Institute of Health Sciences
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Nakamura H
Department Of Analytical Chemistry Hoshi University
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Furukawa F
Division Of Pathology National Institute Of Health Sciences
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Furukawa Fumio
国立衛生試験所
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Furukawa Fumio
Division Of Pathology National Institute Of Health Sciences
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NAKAMURA Hideaki
Division of Pathology, National Institute of Health Sciences
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Hirose Masao
Division Of Pathology National Institute Of Health Sciences
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Ikezaki Shinichiro
Division of Pathology, National Institute of Health Sciences
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Tanakamaru Zen-yo
Division of Pathology, National Institute of Health Sciences
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Nakamura Hideaki
Central Laboratory And Radiation Biology Aichi Cancer Center Research Institute
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Nishikawa Akiyoshi
Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences
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Nakamura Hideaki
Department Of Analytical Chemistry Hoshi University
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Nakamura Hideaki
Central Laboratory And Radiation Biology Aichi Cancer Center Research Institute Kanokoden
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Mori Hideki
Department Of Anatomy Okayama University Medical School
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Tanakamaru Zen-yo
Division Of Pathology National Institute Of Health Sciences:department Of Pathology Gifu University
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Ikezaki Shinichiro
Division Of Pathology National Institute Of Health Sciences:department Of Pathology Gifu University
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Nakamura Hajime
Gastroenterological Surgery Nagoya University Graduate School Of Medicine
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Nakamura Hideaki
Department of Analytical Chemistry, Hoshi University
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NAKAMURA Hideaki
Department of Physics, Kumamoto University
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Mori Hideki
Department of Pathology, Gifu University School of Medicine
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Nakamura Hideaki
Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Medicine), Graduate School of Medicine, University of the Ryukyus, Japan
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