Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats

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概要

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• Effects of octreotide acetate, a somatostatin analog, on the development of spontaneous pancreatitis were investigated in WBN/Kob rats. Delivery of the agent continuously for 28 days via osmotic pumps implanted subcutaneously at 6 μg/day (group 1), 3 μg/day (group 2) or 0 μg/day (saline) (group 3) resulted in comparable body weight gain in all three groups. Relative weights of the liver, kidney, testis, spleen and pancreas also did not significantly differ between the treatments. Blood glucose levels were lowered by the high, but not the low dose treatment, while plasma somatostatin levels were remarkably increased in both the octreotide treatment groups. Remarkable hemorrhage, inflammatory cell infiltration, fibrosis, vacuolation of acinar cells and ductular proliferation were observed in the pancreas of control rats in group 3. However, these findings were consistently less intense in the octreotide treatment groups, in line with morphometric data showing fibrotic areas to be significantly (P<0.01) reduced. Immunohistochemically, collagen fibers in the intralobular space were mainly of type-III and mixed with α-smooth muscle actin, reflecting fibrosis in all groups. The present experiment demonstrated that octreotide inhibits spontaneous pancreatitis in WBN/Kob rats.

• 日本毒性病理学会の論文
• 2007-03-30

著者

• Hirose Masao

  Division of Pathology, National Institute of Health Sciences

• Nishikawa Akiyoshi

  Division of Pathology, National Institute of Health Sciences

• Mori H

  Division Of Pathology National Institute Of Health Sciences

• FURUKAWA Fumio

  Division of Pathology, National Institute of Health Sciences

• ABE Hiroshi

  Department of Pathology, Juntendo University School of Medicine

• Abe Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Hirose Masao

  国立医薬品食品衛生研究所 病理

• Hirose M

  Division Of Pathology National Institute Of Health Sciences:food Safety Commission

• Hirose Masao

  国立医薬品食品衛生研究所 病理部

• Hirose Masao

  名古屋市立大学 医学研究科実験病態病理学

• Furukawa F

  Division Of Pathology National Institute Of Health Sciences

• Furukawa Fumio

  国立衛生試験所

• Furukawa Fumio

  Division Of Pathology National Institute Of Health Sciences

• Mori Hideki

  岐阜薬科大学 生物薬学研究所

• Makita Hiroki

  岐阜大学 第1病理

• Hirose Masao

  Division Of Pathology National Institute Of Health Sciences

• Hirose Masao

  Div. Pathol. Natl. Inst. Htlh. Sci.

• Hirota M

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• Nishikawa A

  Div. Of Pathology National Inst. Of Health Sciences

• Nishikawa Akiyoshi

  Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences

• Nishikawa A

  National Inst. Health Sci. Tokyo Jpn

• Hosono M

  Aburahi Laboratories Shionogi Research Laboratories Shionogi Co Ltd.

• Nishikawa A

  National Institute Of Health Science Osaka Branch National Institute Of Health Sciences

• Mori Hideki

  College Of Engineering Graduate School Of Osaka Prefecture University

• Abe Hiroshi

  Department Of Anatomy Akita University School Of Medicine

• Mori Hideki

  First Department Of Pathology Gifu University School Of Medicine

• Abe Hiroshi

  Department Of Anatomy Akita University Graduate School Of Medicine And Faculty Of Medicine

• Abe Hiroshi

  Department Of Pathology Juntendo University School Of Medicine

• Abe Hiroshi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University

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