Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
スポンサーリンク
概要
- 論文の詳細を見る
Effects of octreotide acetate, a somatostatin analog, on the development of spontaneous pancreatitis were investigated in WBN/Kob rats. Delivery of the agent continuously for 28 days via osmotic pumps implanted subcutaneously at 6 μg/day (group 1), 3 μg/day (group 2) or 0 μg/day (saline) (group 3) resulted in comparable body weight gain in all three groups. Relative weights of the liver, kidney, testis, spleen and pancreas also did not significantly differ between the treatments. Blood glucose levels were lowered by the high, but not the low dose treatment, while plasma somatostatin levels were remarkably increased in both the octreotide treatment groups. Remarkable hemorrhage, inflammatory cell infiltration, fibrosis, vacuolation of acinar cells and ductular proliferation were observed in the pancreas of control rats in group 3. However, these findings were consistently less intense in the octreotide treatment groups, in line with morphometric data showing fibrotic areas to be significantly (P<0.01) reduced. Immunohistochemically, collagen fibers in the intralobular space were mainly of type-III and mixed with α-smooth muscle actin, reflecting fibrosis in all groups. The present experiment demonstrated that octreotide inhibits spontaneous pancreatitis in WBN/Kob rats.
- 日本毒性病理学会の論文
- 2007-03-30
著者
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Hirose Masao
Division of Pathology, National Institute of Health Sciences
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Nishikawa Akiyoshi
Division of Pathology, National Institute of Health Sciences
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Mori H
Division Of Pathology National Institute Of Health Sciences
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FURUKAWA Fumio
Division of Pathology, National Institute of Health Sciences
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ABE Hiroshi
Department of Pathology, Juntendo University School of Medicine
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Abe Hiroshi
Department Of Cardiology National Cardiovascular Center
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Hirose Masao
国立医薬品食品衛生研究所 病理
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Hirose M
Division Of Pathology National Institute Of Health Sciences:food Safety Commission
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Hirose Masao
国立医薬品食品衛生研究所 病理部
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Hirose Masao
名古屋市立大学 医学研究科実験病態病理学
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Furukawa F
Division Of Pathology National Institute Of Health Sciences
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Furukawa Fumio
国立衛生試験所
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Furukawa Fumio
Division Of Pathology National Institute Of Health Sciences
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Mori Hideki
岐阜薬科大学 生物薬学研究所
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Makita Hiroki
岐阜大学 第1病理
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Hirose Masao
Division Of Pathology National Institute Of Health Sciences
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Hirose Masao
Div. Pathol. Natl. Inst. Htlh. Sci.
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Hirota M
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Nishikawa A
Div. Of Pathology National Inst. Of Health Sciences
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Nishikawa Akiyoshi
Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences
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Nishikawa A
National Inst. Health Sci. Tokyo Jpn
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Hosono M
Aburahi Laboratories Shionogi Research Laboratories Shionogi Co Ltd.
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Nishikawa A
National Institute Of Health Science Osaka Branch National Institute Of Health Sciences
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Mori Hideki
College Of Engineering Graduate School Of Osaka Prefecture University
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Abe Hiroshi
Department Of Anatomy Akita University School Of Medicine
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Mori Hideki
First Department Of Pathology Gifu University School Of Medicine
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Abe Hiroshi
Department Of Anatomy Akita University Graduate School Of Medicine And Faculty Of Medicine
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Abe Hiroshi
Department Of Pathology Juntendo University School Of Medicine
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Abe Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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