A Review of Nomenclature and Diagnostic Criteria for Proliferative Lesions in the Liver of Rats by a Working Group of the Japanese Society of Toxicologic Pathology
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概要
- 論文の詳細を見る
The final version of the international harmonized nomenclature for proliferative lesions in rats was issued on June 21, 2000. The recommended nomenclature for proliferative lesions in the liver includes focus of cellular alteration, regenerative hepatocellular hyperplasia, cholangiofibrosis, cholangiofibroma, oval cell hyperplasia, hepatocellular adenoma, hepatocellular carcinoma, bile duct hyperplasia, cholangioma, cholangiocarcinoma, hepatocholangiocellular adenoma, and hepatocholangiocellular carcinoma. Foci of cellular alteration are further classified into the following phenotypes: amphophilic, diffusely basophilic, tigroid basophilic, clear cell, eosinophilic, and mixed (basophilic/eosinophilic). Hepatocellular carcinomas are divided into 3 types based on their growth patterns: acinar, solid, and trabecular. In consideration of this international harmonized nomenclature, the current classification, terminology, and diagnostic criteria for prolifrative lesions in the liver of rats recommended by the Japanese Society of Toxicologic Pathology (JSTP) were reviewed by a Working Group of the JSTP. The hepatic proliferative lesions reviewed by the present Working Group included lesions of hepatocellular, cholangiocellular, mixed hepatocholangiocellular, sinusoidal, and hemangioendothelial origins. Any comments and questions on these lesions were discussed among pathologists in the Working Group and the results of discussions were presented at the 1st seminar on the continuing education program of the JSTP in November 2000.
- 日本毒性病理学会の論文
- 2003-03-30
著者
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Nishikawa Akiyoshi
Division of Pathology, National Institute of Health Sciences
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NAKAE Dai
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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Nakae Dai
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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IMAIDA katsumi
Department of Pathology, Nagoya City University Medical School
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Imaida Katsumi
Department Of Onco-pathology Faculty Of Medicine Kagawa University
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Nakae Dai
Department Of Pathology Sasaki Institute Sasaki Foundation
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HARADA Takanori
Toxicology Division, Institute of Environmental Toxicology
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Narama Isao
Research Institute Of Drug Safety Setsunan University
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Nishikawa Akiyoshi
Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences
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IWATA Hijiri
Department of Pathology, Biosafety Research Center, Foods, Drugs and Pesticides
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Imaida Katsumi
Department Of Pathology And Host-defense Onco-pathology Kagawa Medical University
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Iwata Hijiri
Department Of Pathology Biosafety Research Center Foods Drugs And Pesticides
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Iwata Hijiri
Department Of Pathology Biosafety Research Center
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Harada Takanori
Toxicology Division Ii Institute Of Environmental Toxicology
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Harada Takanori
Toxicol. Div. The Inst. Environ. Toxicol.
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