Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats

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• Acrylamide (AA) has been reported to be formed in fried and baked foods with various concentrations, and exposure levels to AA from cooked foods in children are estimated to be higher than those in adults. In order to evaluate the carcinogenicity of AA exposure during childhood, we conducted a medium-term carcinogenicity study with prepubertal administration of AA followed by treatments of a multi-organ-targeted genotoxic carcinogen and a promoting agent for thyroid carcinogenesis in rats. A total of 36 postpartum F344 rats were given drinking water containing AA at 0, 20, 40 or 80 ppm for 3 weeks during the lactation period, and their weaned offspring received the same AA-containing water for 3 more weeks. Offspring were then injected with N-methyl-N-nitrosourea (MNU; 40 mg/kg body weight, i.p.) once at week 7 after birth. Half the animals of the 0 and 40 ppm groups were additionally treated with the anti-thyroid agent sulfadimethoxine (SDM; 125 ppm) in the drinking water thereafter. Offspring were subjected to complete necropsy at week 50. All the major organs and macroscopic abnormalities were excised and examined histopathologically. There was no significant difference in the incidences of hyperplastic and neoplastic lesions in the target organs of AA and/or MNU, such as the brain, spinal cord, pituitary gland, thyroid, adrenal glands, uterus, mammary glands, clitoral gland and tunica vaginalis. In conclusion, no significant modifying actions of AA on MNU-induced multi-organ carcinogenesis were exhibited in any organs of rats when exposed prepubertally under the present experimental conditions.

• 日本トキシコロジー学会の論文
• 2010-02-01

著者

• Imai Toshio

  Division of Pathology, National Institute of Health Sciences

• Takami Shigeaki

  Division of Pathology, National Institute of Health Sciences

• Cho Young-Man

  Division of Pathology, National Institute of Health Sciences

• Hirose Masao

  Division of Pathology, National Institute of Health Sciences

• Nishikawa Akiyoshi

  Division of Pathology, National Institute of Health Sciences

• Mori H

  Division Of Pathology National Institute Of Health Sciences

• Hirose Masao

  国立医薬品食品衛生研究所 病理

• Hirose M

  Division Of Pathology National Institute Of Health Sciences:food Safety Commission

• Hirose Masao

  国立医薬品食品衛生研究所 病理部

• Hirose Masao

  名古屋市立大学 医学研究科実験病態病理学

• Cho Young-man

  Division Of Pathology National Institute Of Health Sciences

• Cho Young-man

  国立医薬品食品衛生研究所 病理部

• Hoshi Manabu

  大阪市立大学 医学部病理学

• Mori Hideki

  岐阜薬科大学 生物薬学研究所

• Makita Hiroki

  岐阜大学 第1病理

• Hirose Masao

  Division Of Pathology National Institute Of Health Sciences

• Hirose Masao

  Div. Pathol. Natl. Inst. Htlh. Sci.

• 今井 淑夫

  Division Of Pathology National Institute Of Health Sciences

• 今井 淑夫

  東京工業大学部有機材科工学科

• Hirota M

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• 今井 淑夫

  元 東京工業大学工学部有機材料工学科

• Imai Yoichiro

  Department Of Clinical Biochemistry Fujita Health University College

• Nishikawa A

  Div. Of Pathology National Inst. Of Health Sciences

• Nishikawa Akiyoshi

  Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences

• Nishikawa A

  National Inst. Health Sci. Tokyo Jpn

• Hosono M

  Aburahi Laboratories Shionogi Research Laboratories Shionogi Co Ltd.

• Nishikawa A

  National Institute Of Health Science Osaka Branch National Institute Of Health Sciences

• Mori Hideki

  College Of Engineering Graduate School Of Osaka Prefecture University

• Hirose Masao

  First Department Of Pathology Nagoya City University Medical School

• Hirose Masao

  Department Of Pathology Nagoya Higashi Municipal Hospital

• 今井 淑夫

  東京工業大学

• Takami Shigeaki

  Division Of Pathology National Institute Of Health Sciences

• Mori Hideki

  First Department Of Pathology Gifu University School Of Medicine

• Imai Toshio

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Nishikawa Akiyoshi

  Division Of Pathology Nihs

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