The Utility of N-nitrosamines as Initiators for a 26-Week Rat Two-Stage Nasal Carcinogenesis Model
スポンサーリンク
概要
- 論文の詳細を見る
To examine the utility of N-nitrosamines as initiators for a 26-week two-stage rat nasal carcinogenesis model, male F344 rats were treated with 2,6-dimethylaniline (DMA), possessing promoting potential for the rat nasal cavity, after initiation with 3 subcutaneous injections of 1500 mg/kg of N-bis(2-hydroxypropyl)nitrosamine (DHPN), 30 mg/kg of N-nitrosobis(2-oxypropyl)amine (BOP), or 30 mg/kg of N-nitrosopiperidine (NPIP). Histopathologically diagnosed nasal epithelial hyperplasias and tumors, including carcinomas, were induced with all three, with significant increase in the DHPN+DMA, BOP+DMA, and NPIP+DMA groups compared with the DHPN alone, BOP alone, and NPIP alone groups, respectively. These results strongly suggested that repeated subcutaneous injections of DHPN, BOP, or NPIP are useful for initiation in the present 26-week nasal carcinogenesis model.
- 日本毒性病理学会の論文
- 2002-03-25
著者
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Hirose Masao
Division of Pathology, National Institute of Health Sciences
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Mori H
Division Of Pathology National Institute Of Health Sciences
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ONODERA Hiroshi
Division of Pathology, National Institute of Health Sciences
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Yasuhara K
Division Of Pathology National Institute Of Health Sciences
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Yasuhara Kazuo
Divisions Of Toxicology National Institute Of Hygienic Sciences
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Yasuhara Kazuo
Division Of Pathology National Institute Of Health Sciences
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TAKAGI Hisayoshi
Division of Pathology, National Institute of Health Sciences
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TAMURA Toru
Division of Pathology, National Institute of Health Sciences
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MITSUMORI Kunitoshi
Division of Pathology, National Institute of Health Sciences
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Takizawa Tamotsu
東京農工大学
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Takizawa Tamotsu
Division Of Pathology National Institute Of Health
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Takizawa Tamotsu
Division Of Pathology National Institute Of Health Sciences
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Hirose Masao
国立医薬品食品衛生研究所 病理
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Koujitani Takatoshi
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 1
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Tamura Toru
Division Of Pathology National Institute Of Health Sciences
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Takagi Hisayoshi
国立医薬品食品衛生研究所
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Takagi Hisayoshi
Division Of Pathology National Institute Of Health Sciences
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Onodera Hiroshi
東京都健康安全研究センター
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小野寺 博志
Division Of Pathology National Institute Of Health Sciences
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Onodera Hiroshi
Pharmaceuticals And Medical Devices Agency
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糀谷 高敏
Division Of Pathology National Institute Of Health Sciences
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Koujitani Takatoshi
国立医薬品食品衛生研究所
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Koujitani Takatoshi
Division Of Pathology National Institute Of Health Sciences
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Tamura Tomohide
Medical Oncology Division National Cancer Center Hospital
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Kodama Yukio
Division Of Pathology National Institute Of Health Sciences
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Kitamura Y
Division Of Pathology National Institute Of Health Sciences
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Hirose Masao
Division Of Pathology National Institute Of Health Sciences
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Hirose Masao
Div. Pathol. Natl. Inst. Htlh. Sci.
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Mitsumori Kunitoshi
Division Of Pathology National Institute Of Health Sciences
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Kamimura Yasuhiro
Safety Evaluation Lab. Yoshitomi Pharm.
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Onodera H
Pharmaceuticals And Medical Devices Agency
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Kashida Y
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Kawasaki Yasushi
Div.of Toxicol. National Institute Of Health Sciences
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Matsumoto K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Onodera Hiroshi
Dvision Of Pathology Biological Safety Research Center National Institute Of Health Sciences
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Yasuhara Kazuo
Division Of Medicinal Chemistry And Pharmacognosy Ohio State University
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Tamura Toru
Div. Of Pathology Nihs
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Tamura Toru
Division Of Pathology National Institute Of Health
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