Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain

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概要

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• The present study was performed to assess the protective role of thioredoxin/adult T-cell leukemia-derived factor (TRX/ADF) on the liver and brain cell damages induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in ADF wild-type (WT) and transgenic (Tg) mice. The ADF WT and Tg mice were intraperitoneally injected with a single dose of TCDD (150 μg/kg body weight). One day after the treatment, the liver and brain tissues were examined electron microscopically to evaluate the cellular toxicity. In the ADF WT mice, marked reduction of subcellular components, such as mitochondria, rough endoplasmic reticula, and glycogen granules, as well as swelling of the remaining mitochondria, were evident in the liver cells. However, attenuation of these changes was evident in TCDD-treated TRX/ADF mice. Similar subcellular changes noted in the neuronal cells of TCDD-treated WT mice were also attenuated in Tg mice. The results suggest that oxidative cellular damage contributes to the acute toxicity induced by TCDD and that TRX/ADF protects against it.

• 日本毒性病理学会の論文
• 2005-03-30

著者

• Mori H

  Division Of Pathology National Institute Of Health Sciences

• IMAZAWA Takayoshi

  Division of Pathology, National Institute of Health Sciences

• KODAMA Yukio

  Division of Toxicology, National Institute of Health Sciences

• YOON Byung-Il

  Division of Cellular and Molecular Toxicology, Kangwon National University

• KANEKO Toyozo

  Division of Cellular and Molecular Toxicology, Kangwon National University

• HIRABAYASHI Yoko

  Division of Cellular and Molecular Toxicology, Kangwon National University

• IMAZAWA Takayoshi

  Department of Pathology, Kangwon National University

• NISHIKAWA Akiyoshi

  Department of Pathology, Kangwon National University

• KANNO Jun

  Division of Cellular and Molecular Toxicology, Kangwon National University

• YODOI Junji

  Department of Biological Responses, Institute for Virus Research, Kyoto University

• HAN Jeong-Hee

  Department of Veterinary Medicine, Kangwon National University

• HIROSE Masao

  Department of Pathology, Kangwon National University

• INOUE Tohru

  Safety and Research Center of National Institute of Health Sciences

• Yasuhara Kazuo

  Division Of Pathology National Institute Of Health Sciences

• Hirose M

  Division Of Pathology National Institute Of Health Sciences:food Safety Commission

• Hirabayashi Yoko

  Division Of Cellular And Molecular Toxicology Kangwon National University

• Imazawa T

  Division Of Pathology National Institute Of Health Sciences

• Imazawa Takayoshi

  国立医薬品食品衛生研究所 病理部

• KAWASAKI Yasushi

  Div of Cellular and Molecular Toxicology

• KANEKO Toyozo

  National Center for Drug Safety Evaluation

• Yodoi Junji

  Department Of Biological Responses Institute For Virus Research Kyoto University

• INOUE Tohru

  Center for Biological Safety and Research

• Kodama Yukio

  Division Of Pathology National Institute Of Health Sciences

• Kitamura Y

  Division Of Pathology National Institute Of Health Sciences

• Makita Hiroki

  岐阜大学 第1病理

• Kurokawa Y

  Division Of Toxicology National Institute Of Health Sciences

• Hirose Masao

  Division Of Pathology National Institute Of Health Sciences

• Kanno Jun

  Division Of Molecular Toxicology National Institute Of Health Sciences

• Kanno Jun

  New Business Development Biacore K. K.

• Yoon Byung-il

  Division Of Cellular And Molecular Toxicology Kangwon National University

• Nishikawa A

  Div. Of Pathology National Inst. Of Health Sciences

• Nishikawa A

  National Inst. Health Sci. Tokyo Jpn

• Nishikawa A

  National Institute Of Health Science Osaka Branch National Institute Of Health Sciences

• Kodama Yukio

  Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences

• Hirose Masao

  Department Of Pathology Nagoya Higashi Municipal Hospital

• Han Jeong-hee

  Department Of Veterinary Medicine Kangwon National University

• Kanno Jun

  国立医薬品食品衛生研究所安全性生物試験研究センター

• Ikeda Takako

  Division Of Pathology National Institute Of Health Sciences

• Kaneko Toyozo

  Division Of Cellular And Molecular Toxicology Kangwon National University

• Kaneko Toyozo

  Dlv. Of Toxicology Biological Safety Reseach Center National Institute Of Hygienic Sciences

• Kuroiwa Yuichi

  Division Of Pathology National Institute Of Health Sciences

• Kurokawa Yuji

  Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences

• Kaneko Toyozo

  Division Of Cellular & Molecular Toxicology Center For Biological Safety Research National Insti

• Kaneko T

  Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences

• Kanno Jun

  Cel. Mol. Tox. Div. Nihs

• Han Jeong-hee

  Department Of Velterinary Medicine Kangwon National University

• Kawasaki Yasushi

  Div.of Toxicol. National Institute Of Health Sciences

• Mori Hideki

  First Department Of Pathology Gifu University School Of Medicine

• Kanno Jun

  Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute

• Kanno Jun

  Division Of Toxicology National Institute Of Health Sciences

• Hirose Masao

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Inoue Tohru

  New Business Development Biacore K. K.

• Kanno Jun

  Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute

• Yoon Byung-il

  Division Of Cell And Molecular Pathogenesis Department Of Pathology Virginia Commonwealth University

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