RELATIONSHIP BETWEEN TOXICITY AND CADMIUM ACCUMULATION IN RATS GIVEN LOW AMOUNTS OF CADMIUM CHLORIDE OR CADMIUM-POLLUTED RICE FOR 22 MONTHS
スポンサーリンク
概要
- 論文の詳細を見る
To clarify toxic effects of long-term oral administration of low dose cadmium(Cd)on the liver and kidney, six groups of female Sprague-Dawley rats were fed a diet containing Cd-polluted rice or CdCl_2 at concentrations up to 40 ppm, and killed after 12, 18, and 22 months. With toxicological parameters, including histophthology, there was no evidence of Cd-related hepato-renal toxicity, despite a slight decrease of mean corpuscular volume and mean corpuscular hemoglobin of red blood cells with 40 ppm CdCl_2. Dose-dependent accumulation of Cd was observed in the liver and kidneys with peak levels of 130±42 μg/g and 120±20 μg/g, respectively, at 18 months in animals treated with 40 ppm CdCl_2. A dose-dependent increase in urinary Cd levels became evident with time. Induction of metallothionein(MT)was also observed in the liver and kidney with a high correlation to the corresponding Cd levels. In the proximal renal tubular epithelia of 40 ppm CdCl_2-treated rats at 22 months, prominent accumulation of Cd was observed in secondary lysosomes associated with MT deposits in their exocytotic residual bodies. The results demonstrated that, in contrast to the case with high-dose Cd-administration, renal toxicity is not induced by long-term oral administration of low amounts of Cd, although tissue accumulation does occur. Possible protective mechanisms may be operating.
- 日本トキシコロジー学会の論文
- 2001-12-21
著者
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
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IMAZAWA Takayoshi
Division of Pathology, National Institute of Health Sciences
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MITSUMORI Kunitoshi
Division of Pathology, National Institute of Health Sciences
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Mitsumori Kunitoshi
杏林製薬研究センター
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Imazawa Takayoshi
Division Of Pathology National Institute Of Health Sciences
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Shibutani Makoto
Division of Biochemistry and Immunochemistry, National Institute of Health Sciences
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SATOH Masahiko
Environmental Health Sciences Division, National Institute for Environmental Studies
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Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
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SEO Makoto
Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University
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MITSUMORI Kunitoshi
Institute of Environmental Toxicology
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Ando Masanori
Division of Environmental Chemistry, National Institute of Health Sciences
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Mitsumori Kunitoshi
Division Of Pathology National Institute Of Health Sciences
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Seo Makoto
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Satoh Masahiko
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Satoh Masahiko
Environmental Health Sciences Division National Institute For Environmental Studies
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Akagi Takumi
Laboratory For Neural Architecture Brain Science Institute Riken
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Satoh Masahiko
Lab. Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin Univ.
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SATOH Shin-ichi
Second Laboratory, Ina Research Inc.
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HIRATSUKA Hideaki
Mitsubishi Chemical Safety Institute Ltd.
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SUMIYOSHI Masami
Division of Inorganic Chemicals, Tama Laboratory, Japan Food Research Laboratories
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NISHIJIMA Motohiro
Division of Food Sanitation, The Tokyo Metropolitan Research Laboratory of Public Health
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KATSUKI Yasutaka
Division of Food Sanitation, The Tokyo Metropolitan Research Laboratory of Public Health
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SUZUKI Jin
Division of Food Sanitation, The Tokyo Metropolitan Research Laboratory of Public Health
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NAKAGAWA Jun-ichi
Division of Food Sanitation, The Tokyo Metropolitan Research Laboratory of Public Health
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Suzuki Jin
Division Of Food Sanitation The Tokyo Metropolitan Research Laboratory Of Public Health
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Sato Shin-ichi
Second Laboratory Ina Research Inc.
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Shibutani Makoto
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Shibutani Makoto
Division Of Pathology National Institute Of Health Sciences
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Shibutani Makoto
Division Of Biochemistry And Immunochemistry National Institute Of Health Sciences:(present Office)l
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Katsuki Yasutaka
Division Of Food Sanitation The Tokyo Metropolitan Research Laboratory Of Public Health
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Hiratsuka Hideaki
Kashima Laboratory Of Mitsubishi Chemical Safety Institute Ltd.
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Nishijima Motohiro
Division Of Food Sanitation The Tokyo Metropolitan Research Laboratory Of Public Health
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Imazawa Takayoshi
Division Of Pathology Biological Safety Research Center National Institute Of Health Sciences
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三森 国敏
Division Of Pathology National Institute Of Health Sciences
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Nakagawa Jun-ichi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Ando Masanori
Division Of Environmental Chemistry National Institute Of Health Science
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Satoh Masahiko
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Nakagawa Jun-ichi
Division Of Food Sanitation The Tokyo Metropolitan Research Laboratory Of Public Health
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Mitsumori K
The Institute Of Environmental Toxicology:agrotox Inc.
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Sumiyoshi Masami
Division Of Inorganic Chemicals Tama Laboratory Japan Food Research Laboratories
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