THIRTEEN-WEEK REPEATED DOSE TOXICITY STUDY OF WORMWOOD (ARTEMISIA ABSINTHIUM) EXTRACT IN RATS
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概要
- 論文の詳細を見る
Wormwood, Artemisia absinthium, is a very bitter plant, and its extract has been used as food additives such as seasonings for food and drinks. A 1 3-week repeated dose toxicity study of wormwood extract was performed in both sexes of Wistar Hannover (GALAS) rats. Rats were divided into 4 groups consisting of 10 males and 10 females each, and were given water containing 0, 0.125, 0.5, or 2% wormwood extract. All rats had survived at the end of the study, and no changes indicating obvious toxicities that are attributable to the treatment of wormwood extract were observed in the body weights, hematological and serum biochemical examinations, organ weights, and histopathological examinations. Based on the results of the present study, the NOAEL (no-observed-adverse-effect-level) of wormwood extract of Wistar Hannover rats was estimated to be 2% (equivalent to 1.27 g/kg/day in males and 2.06 g/kg/day in females) or more.
- 日本トキシコロジー学会の論文
- 2003-12-26
著者
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MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Mitsumori Kunitoshi
東京大学医科学研究所 癌細胞シグナル分野
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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OKAMURA Miwa
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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WATANABE Takao
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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KASHIDA Yoko
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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MOTO Mitsuyoshi
Laboratory of Veterinary of Pathology, Tokyo University of Agriculture and Technology
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Muto Tomoko
麻布大学 獣医学部比較毒性学
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武藤 朋子
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Muto Tomoko
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Muto Tomoko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Muto Tomoko
Comparative Toxicology Laboratories Azabu University School Of Veterinary Medicine
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Yasuhara Kazuo
Divisions Of Toxicology National Institute Of Hygienic Sciences
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Yasuhara Kazuo
Division Of Pathology National Institute Of Health Sciences
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Moto Mitsuyoshi
東京農工大学 獣医病理学
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Moto Mitsuyoshi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Muguruma Masako
東京農工大学 獣医病理学
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Watanabe Takao
Laboratory Of Veterinary Pathology Faculty Of Agriculture Tokyo University Of Agriculture And Techno
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Kodama Yukio
Division Of Pathology National Institute Of Health Sciences
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Kitamura Y
Division Of Pathology National Institute Of Health Sciences
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Okamura Miwa
東京農工大学 農学部獣医病理学研究室
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安原 加壽雄
San-ei Gen F.f.i. Inc.
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Kurokawa Y
Division Of Toxicology National Institute Of Health Sciences
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Mitsumori Kunitoshi
Department Of Pathology National Institute Of Health Sciences
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Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec
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Kamimura Yasuhiro
Safety Evaluation Lab. Yoshitomi Pharm.
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Okamura Miwa
Laboratory Of Veterinary Pathology Faculty Of Agriculture Tokyo University Of Agriculture And Techno
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Matsumoto K
Drug Safety Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.:l
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三森 国敏
Division Of Pathology National Institute Of Health Sciences
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Kashida Y
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Kodama Yukio
Cel. Mol. Tox. Div. Nihs
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Matsumoto K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Watanabe Tomoyuki
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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