Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
スポンサーリンク
概要
- 論文の詳細を見る
7,12-Dimethybenz[a]anthracene (DMBA) is an indirect carcinogen that enlists the host metabolism to produce its ultimate carcinogenic form, and it is known that this metabolism is conducted by cytochrome P450 1A1 and/or 1B1(CYP1). However, the time course of expression of rat liver CYP1 following DMBA administration has been unclear. After DMBA administration (100 mg/kg b.w.) to SD rats, expression of liver CYP1mRNA was observed at 6 hr and gradually increased with time to peak on days 1-2, but then disappeared on day 5. Expression of CYP1A1 protein was first observed at 12 hr, peaked on day 2 and decreased on day 5, while expression of CYP1B1 protein was first observed on day 2 and decreased on day 5. Expression levels of CYP1A1mRNA and protein were higher than those of CYP1B1. The present study suggests that high CYP1 enzyme production and DMBA metabolism might occur in rat liver substantially on day 2 following DMBA administration.
- 日本毒性病理学会の論文
- 2003-12-30
著者
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MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Mitsumori Kunitoshi
東京大学医科学研究所 癌細胞シグナル分野
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OKAMURA Miwa
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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MOTO Mitsuyoshi
Laboratory of Veterinary of Pathology, Tokyo University of Agriculture and Technology
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Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Muto Tomoko
麻布大学 獣医学部比較毒性学
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武藤 朋子
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Muto Tomoko
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Muto Tomoko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Muto Tomoko
Comparative Toxicology Laboratories Azabu University School Of Veterinary Medicine
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Yasuhara Kazuo
Divisions Of Toxicology National Institute Of Hygienic Sciences
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Yasuhara Kazuo
Division Of Pathology National Institute Of Health Sciences
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三森 国敏
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Mitsumori Kunitoshi
杏林製薬研究センター
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Moto Mitsuyoshi
東京農工大学 獣医病理学
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Moto Mitsuyoshi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Muguruma Masako
東京農工大学 獣医病理学
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Watanabe Takao
Laboratory Of Veterinary Pathology Faculty Of Agriculture Tokyo University Of Agriculture And Techno
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KANAI Yoshikatsu
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Kodama Yukio
Division Of Pathology National Institute Of Health Sciences
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Okamura Miwa
東京農工大学 農学部獣医病理学研究室
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Endou Hitoshi
群馬大学 医学系研究科病態制御内科学
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Endou Hitoshi
杏林大学 医学部薬理学教室
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安原 加壽雄
San-ei Gen F.f.i. Inc.
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Kurokawa Y
Division Of Toxicology National Institute Of Health Sciences
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Mitsumori Kunitoshi
Department Of Pathology National Institute Of Health Sciences
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Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec
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Watanabe Toshi
Departments Of Veterinary Biochemistry College Of Bioresource Sciences Nihon University
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KASHIDA Youko
Laboratory of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Tech
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Endou H
Kyorin Univ. School Of Medicine Tokyo Jpn
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Endou Hitoshi
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Kanai Yoshikatsu
Department Of Pharmacol. Toxicol. Kyorin Univ.
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Kamimura Yasuhiro
Safety Evaluation Lab. Yoshitomi Pharm.
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Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Okamura Miwa
Laboratory Of Veterinary Pathology Faculty Of Agriculture Tokyo University Of Agriculture And Techno
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Matsumoto K
Drug Safety Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.:l
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Kuroiwa Yuichi
Division Of Pathology National Institute Of Health Sciences
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Kashida Y
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Kodama Yukio
Cel. Mol. Tox. Div. Nihs
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Matsumoto K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Kanai Yoshikatsu
Division Of Bio-system Pharmacology Department Of Pharmacology Osaka University Graduate School Of M
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Watanabe Tomoyuki
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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