Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate
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概要
- 論文の詳細を見る
In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver. When expressed in Xenopus oocytes, mOat2-mediated [3H]PGE2 transport was inhibited by three- to five-carbon SCFAs (C3 to C5). Among the SCFAs tested, propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner. Since propionate is a potent glucogenic compound, Oat2 may be involved in the regulation of cellular metabolism through the transport of these metabolites in the kidneys and the liver.
- 社団法人 日本薬理学会の論文
- 2008-03-20
著者
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Babu Ellappan
杏林大学 医学部薬理学
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Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Anzai Naohiko
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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安西 尚彦
杏林大学医学部薬理学教室
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Miura Daisaku
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Fukutomi Toshiyuki
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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KANAI Yoshikatsu
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Endou Hitoshi
群馬大学 医学系研究科病態制御内科学
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Endou Hitoshi
杏林大学 医学部薬理学教室
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Miura Daisaku
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Islam Rafiqul
Department of Pharmacolgy and Toxicology, Kyorin University, School Of Medicine
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Babu Ellappan
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Babu Ellappan
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Jin Chun
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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AHMED Nesar
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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ELLAPAN Babu
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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SRIVASTAVA Sunena
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Kanai Yoshikatsu
Department Of Pharmacol. Toxicol. Kyorin Univ.
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Fukutomi Toshiyuki
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Islam Rafiqul
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Ahmed Nesar
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Islam Rafiqul
Department Of Host-defense Biochemistry Institute Of Tropical Medicine Nagasaki University
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Kanai Yoshikatsu
Division Of Bio-system Pharmacology Department Of Pharmacology Osaka University Graduate School Of M
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Anzai Naohiko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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安西 尚彦
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Srivastava Sunena
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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