Interactions of Human-and Rat-Organic Anion Transporters With Pravastatin and Cimetidine
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概要
- 論文の詳細を見る
We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1 and hOAT2, whereas it was competitive for hOAT3 and hOAT4. Cimetidine also inhibited hOAT1/rOAT1, hOAT3/rOAT3, and hOAT4. The mode of inhibition was a combination of competitive and noncompetitive manners for hOAT1, whereas it was competitive for hOAT3. The effects of OAT inhibitors on OAT1, OAT2, and OAT3 exhibited some but not so remarkable interspecies differences between humans and rats. In conclusion, we have characterized pravastatin and cimetidine as OAT inhibitors.
- 社団法人 日本薬理学会の論文
- 2004-02-01
著者
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Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Takeda Michio
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Endou Hitoshi
群馬大学 医学系研究科病態制御内科学
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Endou Hitoshi
杏林大学 医学部薬理学教室
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ENOMOTO Atsushi
Department of Pathology, Nagoya University Graduate School of Medicine
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Takeda Michio
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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KHAMDANG Suparat
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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NOSHIRO Rie
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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NARIKAWA Shinichi
Kobuchizawa Laboratories, Fuji Biomedixs Co.
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HUANG Xiu-Lin
Kobuchizawa Laboratories, Fuji Biomedixs Co.
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Tsuda Minoru
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Endou Hitoshi
Departmentof Pharmacology And Toxicology Kyorin Universitv School Of Medicine
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Huang Xiu-lin
Kobuchizawa Laboratories Fuji Biomedixs Co.
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Noshiro Rie
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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SHIMODA MINORU
Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Techn
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Shimoda Minoru
Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technol
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PIYACHATURAWAT Pawinee
Department of Physiology, Faculty of Science, Mahidol University
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Piyachaturawat Pawinee
Department Of Physiology Faculty Of Science Mahidol University
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Enomoto Atsushi
Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University
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Enomoto Atsushi
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Khamdang Suparat
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Takeda M
Pharmaceutical Laboratory Sanwa Kagaku Kenkyusho Co. Ltd
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Narikawa Shinichi
Kobuchizawa Laboratories Fuji Biomedixs Co.
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Shimoda Minoru
Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technol
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ENOMOTO ATSUSHI
Department of Clinical Preventive Medicine, Nagoya Univesity Hospital:Departmentof Pharmacology and Toxicology, Kyorin Universitv School of Medicine
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