Organic Anion Transporter Family : Current Knowledge
スポンサーリンク
概要
- 論文の詳細を見る
Organic anion transporters (OATs) play an essential role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many drugs and their metabolites that are important in clinical medicine. Several families of multispecific organic anion and cation transporters, including OAT family transporters, have recently been identified by molecular cloning. The OAT family consists of six isoforms (OAT1 – 4, URAT1, and rodent Oat5) and they are all expressed in the kidney, while some are also expressed in the liver, brain, and placenta. The OAT family represents mainly the renal secretory and reabsorptive pathway for organic anions and is also involved in the distribution of organic anions in the body, drug-drug interactions, and toxicity of anionic substances such as nephrotoxic drugs and uremic toxins. In this review, current knowledge of and recent progress in the understanding of several aspects of OAT family members are discussed.
- 社団法人 日本薬理学会の論文
- 2006-05-15
著者
-
Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
-
Anzai Naohiko
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
-
安西 尚彦
杏林大学医学部薬理学教室
-
KANAI Yoshikatsu
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
-
Endou Hitoshi
群馬大学 医学系研究科病態制御内科学
-
Endou Hitoshi
杏林大学 医学部薬理学教室
-
Endou H
Kyorin Univ. School Of Medicine Tokyo Jpn
-
Kanai Yoshikatsu
Department Of Pharmacol. Toxicol. Kyorin Univ.
-
Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
-
Kanai Yoshikatsu
Division Of Bio-system Pharmacology Department Of Pharmacology Osaka University Graduate School Of M
-
Anzai Naohiko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
-
安西 尚彦
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
関連論文
- Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
- 2-I-30 ヒト尿酸トランスポーターhURAT1によるオロト酸輸送の解析(一般演題,日本ビタミン学会第62回大会発表要旨)
- 企画にあたって(ビタミン・バイオファクターのトランスポーター[I])
- Inhibition of L-Type Amino Acid Transporter Modulates the Expression of Cell Cycle Regulatory Factors in KB Oral Cancer Cells
- 胃癌におけるアミノ酸トランスポーター LAT1 (L-type amino acid transporter 1) および4F2hc発現についての免疫組織化学的検討
- Perfluorooctanoic acid の腎排泄における organic anion transporters の役割
- D-2 メタボローム技術を用いた新しいサブファミリーに属する新規有機イオントランスポーターの生理機能の解析(一般口演,第35回杏林医学会総会)
- SLC2A9遺伝子多型と痛風発症の関連についての検討
- 尿酸輸送体NPT1の血清尿酸値と痛風発症との相関に関する検討
- Renal Secretion of Uric Acid by Organic Anion Transporter 2 (OAT2/SLC22A7) in Human
- Children's toxicology from bench to bed - Drug-induced Renal Injury (3) : Drug transporters and toxic nephropathy in childhood
- 新規尿酸トランスポーターURATv1(SLC2A9)遺伝子変異と腎性低尿酸血症
- 新規尿酸排出トランスポーターURATv1の尿酸輸送特性の解析
- 腎臓の尿酸トランスポーター : 最近の進歩
- 高尿酸血症を示すヒト肝細胞キメラマウス腎臓のプロテオーム解析
- ヒト尿酸トランスポーターURAT1によるサリチル酸輸送
- ヒト肝細胞キメラマウスにおける血中ヒトアルブミン値と血清尿酸値の相関性
- ヒト肝臓キメラマウスにおける血中ヒトアルブミン値と血清尿酸値の相関性に関する検討
- 2-II-14 ヒト有機アニオントランスポーターhOAT2のニコチン酸輸送と肝臓内発現在(一般研究発表,日本ビタミン学会 第58回大会研究発表要旨)
- 尿酸トランスポーターUrat1セミノックインマウスにおける尿酸の体内動態
- 新規ヒト尿酸排出トランスポーターURATv1による尿酸輸送の電気生理学的解析
- 新規ヒト有機酸排出トランスポーターhOATv1の分子同定
- EFFECTS OF Mg AND K DEFICIENCY ON MALE AND FEMALE MICE
- 腎の尿酸輸送とトランスポーター (特集 痛風・高尿酸血症をめぐって)
- 高尿酸血症を示すヒト肝細胞キメラマウスの特徴
- Establishment and Characterization of Mammalian Cell Lines Stably Expressing Human L-Type Amino Acid Transporters
- 有機アニオントランスポーターOAT4によるオロト酸輸送
- 腎尿細管細胞の細胞特性II : 有機溶質の輸送
- ヒト尿酸トランスポーターURAT1によるオロト酸輸送
- 新規尿酸排出トランスポーターURATv1の尿酸輸送特性の解析
- Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
- L-Type Amino Acid Transporter-1 Expressed in Human Astrocytomas, U343MGa(Biochemistry)
- Transport of methylmercury through the epithelial type amino acid transport system B^0(Proceedings of the 32nd Annual Meeting)
- P7-56 Identification of novel system L transporters and their methyl mercury-cysteine conjugates transport properties(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P7-20 Modulatory effects of membrane proteins interacting with essential large neutral amino acids transporter LAT1, on amino acid uptake in bladder transitional cell carcinoma line, T24(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTO
- Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
- Concentration-Dependent Inhibitory Effect of Irbesartan on Renal Uric Acid Transporters
- P-21 Trasport of methyl mercury-cysteine conjugate by multispecific organic anion transport 3(Proceedings of the 27th Annual Meeting)
- Establishment of a Mouse Macula Densa Cell Line with an nNOS Promoter Driving EGFP Expression
- Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate
- Nicergoline Enhances Glutamate Uptake via Glutamate Transporters in Rat Cortical Synaptosomes(Highlighted paper selected by Editor-in chief)(Pharmacology)
- Measurement of Glutamate Uptake and Reversed Transport by Rat Synaptosome Transporters(Pharmacology)
- Correlation of angiogenesis with ^F-FMT and ^F-FDG uptake in non-small cell lung cancer
- Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung
- L-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
- Nephrin and Podocin Expression Around the Onset of Puromycin Aminonucleoside Nephrosis
- RELATIONSHIP BETWEEN γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY IN URINE AND RENAL PROXIMAL TUBULAR DAMAGE(S) BY NEPHROTOXIC AGENTS (The 6th Meeting for the Study of Toxic Effect)
- SUPPRESSIVE EFFECT OF DIPYRIDAMOLE ON THE PROTEINURIA OF AMINONUCLEOSIDE NEPHROSIS IN RAT.
- EFFECTS OF MERCURY ON THE STRUCTURAL GLYCOPROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The 5th Meeting for the Study of Toxic Effect)
- EFFECTS OF MERCURY ON THE STRUCTURAL PROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The Fourth Meeting for the Study of Toxic Effect)
- 215. TOXIC ACTION OF HEAVY METALS. 2. ANALYSIS OF PROTEINURIA DUE TO MERCURY (The Third Meeting for the Study of Toxic Effect)
- 103. EFFECT OF MERCURY ON THE NEWT KIDNEY (The Second Meeting for the Study of Toxic Effect)
- PROGRESS IN NEPHROTOXICOLOGY : FROM IN VIVO SCREENING TEST TO MOLECULAR MECHANISMS
- Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
- Expression of Human Organic Anion Transporters in the Choroid Plexus and Their Interactions With Neurotransmitter Metabolites
- Role of Organic Anion Transporters in the Tubular Transport of Indoxyl Sulfate and the Induction of its Nephrotoxicity.(GENERAL SESSION BY POSTER PRESENTATION)(KIDNEYS AND URINARY EXCRETION SYSTEM)
- Differential Expression of System L Amino Acid Transporters during Wound Healing Process in the Skin of Young and Old Rats(Molecular and Cell Biology)
- O-58 Transport of a methylmercury-cysteine conjugate mediated by system L neutral amino acid transporters(Proceedings of the 27th Annual Meeting)
- Human Organic Anion Transporters Mediate the Transport of Tetracycline
- C-17 IDENTIFICATION OF A NOVEL LIVER SPECIFIC ORGANIC ANION TRANSPORTER SELECTIVE FOR CONJUGATED DRUGS AND STEROID HORMONES
- Testicular Toxicology of Pubescent and Adult Rats Prenatally Exposure to 3,3',4,4',5-Pentachlorobiphenyl
- The role of amino acid transporters in the cytotoxicity of methylmercury.(GENERAL SESSION BY POSTER PRESENTATION)(ENVIRONMENTAL CHEMICALS,HEAVY METALS & CYTOTOXICITY)
- O10-17 Expression of system L amino acid transporters in the blood-tissue barriers and the transport of 35^S-methylmercury.
- Role of Mouse Organic Anion Transporter 3 (mOat3) as a Basolateral Prostaglandin E_2 Transport Pathway
- Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules
- BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells(Molecular and Cell Biology)
- FUNCTIONAL PROPERTIES OF MULTISPECIFIC AMINO ACID TRANSPORTERS AND THEIR IMPLICATIONS TO TRANSPORTER-MEDIATED TOXICTY
- Organic Anion Transporter Family : Current Knowledge
- System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells
- Purinoceptor-Mediated Calcium Mobilization and Cellular Proliferation in Cultured Bovine Corneal Endothelial Cells
- Molecular biology of multispecific organic anion transporter family (OAT family)
- 22D-09-3 Silica increases cytosolic calcium and causes cell injury in renal cell lines.
- Effects of hexavalent chromium on lipid peroxidation and hydroxyl radical generation in mouse kidney.
- Functional Characterization and Immunohistochemical Localization of Organic Anion Transporter 1 (S1c22a6) from Mouse Kidney
- NARCOTIC PHYSICAL DEPENDENCE AND URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
- Current Status and Future Perspective on Molecular Toxicology (KEYNOTE LECTURE) (Proceedings of the 30th Annual Meeting)
- B-12 EFFECT OF MERCURY CHLORIDE ON ANGIOTENSIN II-INDUCED [Ca^]_i INCREASE IN RAT EARLY PROXIMAL TUBULE
- Cis-platinum(II)-diamino dichloride(CDDP) induced toxicity in immortalized cell lines established from each nephron segment of transgenic mice harboring ts-SV40 T-antigen gene.
- Roles of glutamate transporters in neuronal cell death
- W2-1 SIGNIFICANCE OF ALTERNATIVE TOXICITY TESTING
- Human Nramp2 as a cadmium transporter.(GENERAL SESSION BY POSTER PRESENTATION)(ENVIRONMENTAL CHEMICALS,HEAVY METALS & CYTOTOXICITY)
- EVALUATION OF NEPHROTOXICITY
- DISTRIBUTION AND SOME CHARACTERISTICS OF CYTOCHROME P-450 IN THE KIDNEY
- "C-14 The intracellular mechanism for cisplatin-induced apoptosis in renal cell line
- L-Type amino acid transporter 1 inhibitors inhibit tumor cell growth
- Interactions of Human-and Rat-Organic Anion Transporters With Pravastatin and Cimetidine
- Transport of ochratoxin A by renal multispecific organic anion transporter 1 and its effect on cell proliferation
- Development of Renal Potassium Excretion Capacity in the Neonatal Rat
- Interactions of Human Organic Anion Transporters With Aristolochic Acids
- DISTRIBUTION OF GAMMA-GLUTAMYL TRANSPEPTIDASE AND GLUTAMINASE ISOENZYMES IN THE RABBIT SINGLE NEPHRON
- MICROPUNCTURE STUDY OF PROTEIN CONCENTRATION IN GLOMERULAR FLUID IN THE NEWT
- CYTOCHROME P-450 MONOOXYGENASE SYSTEM IN THE RABBIT KIDNEY: ITS INTRANEPHRON LOCALIZATION AND ITS INDUCTION
- Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4
- Interactions of Human Organic Anion Transporters With Aristolochic Acids
- Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
- Human urate transporter 1 (hURAT1) mediates the transport of orotate
- Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
- Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
- A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A
- Uricosuric agents and renal tubular transporters