Concentration-Dependent Inhibitory Effect of Irbesartan on Renal Uric Acid Transporters
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概要
- 論文の詳細を見る
Hyperuricemia is currently recognized as a risk factor for cardiovascular diseases. It has been reported that the angiotensin II–receptor blocker (ARB) losartan decreases serum uric acid level. In this study, the effects of another ARB, irbesartan, on [14C]uric acid–transport activity of renal uric acid reabsorptive transporters URAT1 and URATv1 were examined with Xenopus oocytes expressing each transporter. The results showed that irbesartan (100 – 500 μM) inhibited the uptake of uric acid via both transporters. The inhibitory effects of irbesartan exceeded those of losartan and other ARBs, and the results suggest that irbesartan can reduce serum uric acid level.
- 社団法人 日本薬理学会の論文
著者
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Anzai Naohiko
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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SAKURAI Hiroyuki
Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Med
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安西 尚彦
東京女子医科大学附属膠原病リウマチ･痛風センター
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SATO Hiroyuki
Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo
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安西 尚彦
杏林大学医学部薬理学教室
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Jutabha Promsuk
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Jutabha Promsuk
杏林大学 医学部薬理学
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Nakamura Makiko
Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Japan
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Ichida Kimiyoshi
Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Japan
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Sakurai Hiroyuki
Department Of Hepatobiliary Pancreatic And Transplant Surgery Graduate School Of Medicine Mie Univer
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Anzai Naohiko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Ichida Kimiyoshi
Department Of Pathophysiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Sakurai Hiroyuki
Department Of Biological & Chemical Engineering Gunma University
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Sato Hiroyuki
Department Of Biomolecular Science Fac.sci. Toho Univ.
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Nakamura Makiko
Department Of Pathophysiology Tokyo University Of Pharmacy And Life Sciences
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