Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
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概要
- 論文の詳細を見る
Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often associated with increased cellular accumulation of toxic compounds, and membrane transport may be the first fundamental stage in the development of the cytotoxicity. To elucidate the entry pathway for mycotoxins into cells, we have investigated the interactions of human and rat organic anion transporters (hOATs/rOats) and human organic cation transporters (hOCTs) with mycotoxins using cells stably expressing hOATs/rOats/hOCTs. The mycotoxins tested were aflatoxin B1, α-zearalenol, citrinin, citrioveridine, cyclopiazonic acid, fumonisin B1, gliotoxin, patulin, penicillic acid, rubratoxin B, and zearalenone. These mycotoxins inhibited organic anion uptake mediated by hOAT1-4, and organic cation uptake mediated by hOCT1-2. By comparing the IC50 values of mycotoxins for hOATs, it was found that hOAT1 and hOAT3 exhibited higher affinity interactions with mycotoxins than hOAT2 and hOAT4. There was no interspecies difference between humans and rats for the interactions of OATs with mycotoxins except that of OAT3 with rubratoxin B. Finally, we observed that hOAT1-4 and hOCT1-2 mediated the uptake of aflatoxin B1. In conclusion, hOATs and hOCTs interacted with various mycotoxins. Considering the localization of hOATs/rOats and hOCTs, it was suggested that these transporters were the possible entrance pathway for mycotoxins in kidney and liver, leading to the induction of adverse effects in humans and rats.
- 社団法人 日本薬理学会の論文
- 2008-03-20
著者
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Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Anzai Naohiko
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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安西 尚彦
杏林大学医学部薬理学教室
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Fukutomi Toshiyuki
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Takeda Michio
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Sophasan Samaisukh
杏林大学 医学部薬理学教室
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Sophasan Samaisukh
Department Of Physiology Faculty Of Science Mahidol University
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Sophasan Samaisukh
Department Of Physiology Faculty Of Sciences Mahidol University
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Endou Hitoshi
群馬大学 医学系研究科病態制御内科学
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Takeda Michio
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Endou H
Kyorin Univ. School Of Medicine Tokyo Jpn
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TACHAMPA Kittipong
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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KHAMDANG Suparat
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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NOSHIRO KOFUJI
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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TSUDA Minoru
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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JARIYAWAT Surawat
Department of Physiology, Faculty of Science, Mahidol University
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Tsuda Minoru
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Noshiro Kofuji
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Jariyawat Surawat
Department Of Physiology Faculty Of Science Mahidol University
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Tachampa Kittipong
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Fukutomi Toshiyuki
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Endou Hitoshi
Departmentof Pharmacology And Toxicology Kyorin Universitv School Of Medicine
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Khamdang Suparat
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Tsuda Minoru
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Takeda M
Pharmaceutical Laboratory Sanwa Kagaku Kenkyusho Co. Ltd
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Anzai Naohiko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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安西 尚彦
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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