Testicular Toxicology of Pubescent and Adult Rats Prenatally Exposure to 3,3',4,4',5-Pentachlorobiphenyl

スポンサーリンク

概要

• 論文の詳細を見る

• The present study investigated the dose-response relationship in testicular toxicology of pubescent (7-) and adult (17-week-old) Sprague-Dawley rats whose dams had been injected (i.g.) with 25 pg, 2.5 ng, 250 ng, or 7.5 μg of 3,3,4,4,5-pentachlorobiphenyl (PCB126)/kg or the vehicle on days 13 to 19 post-conception. Rat at 7 and 17 weeks of age of the 7.5 μg group and at 7 weeks of age of the 250 ng group showed an increase in the percentage of seminiferous tubules at Stages VII-VIII. At 7 and 17 weeks of age, rats of the 7.5 μg group showed a decrease in preleptotene spermatocytes with spermatids at all Stages, while animals of the 250 ng group also showed a decrease in preleptotene spermatocytes, but with round spermatids increasing at Stages VI-VII and elongated spermatids decreasing at Stage VIII. At 7 weeks of age, rats of the 2.5 ng group showed an increase in round spermatids at Stages VI-VII. The formation of spermatogenic cells in rats of the 25 pg group was similar to that seen in the vehicle group. The number of Sertoli cells and cauda epididymal sperms in rats of the PCB126 groups were similar to those of the vehicle group. Prenatal PCB126 exposure induced dose-related defective spermatogenesis. A high dose of PCB126 affected the development of spermatogonia and spermatids in puberty and adulthood, while a low dose affected the conversion of spermatids at puberty, although this was recovered in adulthood. Because the serum testosterone levels were similar in the PCB126 and vehicle group rats in puberty and adulthood, a direct endocrine cause for the observed effects was unlikely.

• 日本毒性病理学会の論文
• 2007-09-30

著者

• Endou Hitoshi

  Department of Pharmacology and Toxicology, Kyorin University School of Medicine

• Muto Tomoko

  麻布大学 獣医学部比較毒性学

• 武藤 朋子

  Department Of Pharmacology And Toxicology Kyorin University School Of Medicine

• Muto Tomoko

  Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology

• Muto Tomoko

  Department Of Pharmacology And Toxicology Kyorin University School Of Medicine

• Muto Tomoko

  Comparative Toxicology Laboratories Azabu University School Of Veterinary Medicine

• 和久井 信

  Department Of Toxicology Azabu University School Of Veterinary Medicine

• Yasuhara Kazuo

  Divisions Of Toxicology National Institute Of Hygienic Sciences

• Yasuhara Kazuo

  Division Of Pathology National Institute Of Health Sciences

• 和久井 信

  麻布大学 獣医

• KANAI Yoshikatsu

  Department of Pharmacology and Toxicology, Kyorin University School of Medicine

• Kodama Yukio

  Division Of Pathology National Institute Of Health Sciences

• Kitamura Y

  Division Of Pathology National Institute Of Health Sciences

• WAKUI Shin

  Department of Toxicology, Azabu University School of Veterinary Medicine

• KOBAYASHI Yasuko

  Department of Toxicology, Azabu University School of Veterinary Medicine

• SUZUKI Yoshihiko

  Department of Toxicology, Azabu University School of Veterinary Medicine

• HANO Hiroshi

  Department of Pathology, The Jikei University School of Medicine

• Endou Hitoshi

  杏林大学 医学部薬理学教室

• Endo Hitoshi

  Department Of Pharmacology And Toxicology Kyorin University School Of Medicine

• 安原 加壽雄

  San-ei Gen F.f.i. Inc.

• Wakui Shin

  Department Of Toxicology Azabu University School Of Veterinary Medicine

• Hano Hiroshi

  Department Of Pathology The Jikei University School Of Medicine

• Hano Hiroshi

  Department Of Pathology 1 Jikei University School Of Medicine

• Shirota Kinji

  High-tech Research Project Leaders Azabu University Sagamihara

• Katakura Yoshio

  Department Of Biotechnology Graduate School Of Engineering Osaka University

• Endou H

  Kyorin Univ. School Of Medicine Tokyo Jpn

• Akahori Fumiaki

  High-tech Research Project Leaders Azabu University Sagamihara

• Akagi Yousuke

  Department Of Toxicology Azabu University School Of Veterinary Medicine

• YOKOO Kiyofumi

  Department of Toxicology, Azabu University School of Veterinary Medicine

• HIRONO Shyou

  Department of Toxicology, Azabu University School of Veterinary Medicine

• KAMEI Yousuke

  Department of Toxicology, Azabu University School of Veterinary Medicine

• Hirono Shyou

  Department Of Toxicology Azabu University School Of Veterinary Medicine

• Suzuki Yoshihiko

  Department Of Toxicology Azabu University School Of Veterinary Medicine

• Kanai Yoshikatsu

  Department Of Pharmacology And Toxicology Kyorin University School Of Medicine

• Kanai Yoshikatsu

  Department Of Pharmacol. Toxicol. Kyorin Univ.

• Kamimura Yasuhiro

  Safety Evaluation Lab. Yoshitomi Pharm.

• Yoshikawa Katsunori

  Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka

• Endou Hitoshi

  Department Of Pharmacology & Toxicology Kyorin University School Of Medicine

• Kurokawa Y

  Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences

• Kodama Y

  Biological Safety Research Center National Institute Of Health Science

• Kuroiwa Yuichi

  Division Of Pathology National Institute Of Health Sciences

• Kawasaki Yasushi

  National Institute Of Health Sciences

• Kashida Y

  Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology

• Kurokawa Yuji

  Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences

• Kawasaki Yasushi

  Div.of Toxicol. National Institute Of Health Sciences

• Kodama Yukio

  Cel. Mol. Tox. Div. Nihs

• Yokoo Kiyofumi

  Department Of Toxicology Azabu University School Of Veterinary Medicine

• Kanai Yoshikatsu

  Division Of Bio-system Pharmacology Department Of Pharmacology Osaka University Graduate School Of M

• Kobayashi Yasuko

  Department Of Pediatrics Tohoku University School Of Medicine

• Suzuki Yoshihiko

  Department Of Biochemistry School Of Veterinary Medicine Azabu University

• Suzuki Yoshihiko

  Department Of Biochemistry And Cell Biology Institute Of Development And Aging Sciences Graduate Sch

• Hano Hiroshi

  Department Of Diagnostic Pathology Hokkaido University Hospital

• Kobayashi Yasuko

  Department Of Agricultural And Biological Chemistry College Of Bioresource Sciences Nihon University

• Katakura Yoshio

  Department Of Life Science And Bioengineering Faculty Of Chemistry Materials And Bioengineering Kans

• Yasuhara Kazuo

  Division Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences

• Katakura Yoshio

  Department Of Biotechnology Faculty Of Engineering Osaka University

• Wakui Shin

  Department of Toxicology and Biochemistry, Azabu University School of Veterinary Medicine

関連論文

• Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
• Inhibition of L-Type Amino Acid Transporter Modulates the Expression of Cell Cycle Regulatory Factors in KB Oral Cancer Cells
• Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
• In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
• Catechol enhanced mice hepatotoxicity treated with acetaminophen(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
• Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
• Tumorigenic Susceptibility of Catechol on the Gastric Mucosa in rasH2 Mice
• Children's toxicology from bench to bed - Drug-induced Renal Injury (3) : Drug transporters and toxic nephropathy in childhood
• Lack of Modifying Effect of Glycerol in Pulmonary Carcinogenesis in rasH2 Mice Induced by Urethane or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
• O-16 Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st
• O-16 Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st
• EFFECTS OF Mg AND K DEFICIENCY ON MALE AND FEMALE MICE
• Analysis of Gene Expression Profile on Uterine Tumorigenesis Initiated with N-ethyl-N-nitrosourea and Inhibited by Ethinylestradiol in rasH2 Mice
• THIRTEEN-WEEK REPEATED DOSE TOXICITY STUDY OF WORMWOOD (ARTEMISIA ABSINTHIUM) EXTRACT IN RATS
• Establishment and Characterization of Mammalian Cell Lines Stably Expressing Human L-Type Amino Acid Transporters
• Testicular spermiation failure in rats exposed prenatally to 3,3',4,4',5-pentachlorobiphenyl
• O-12 Molecular pathological analyses on hepatocarcinogenesis induced by dicyclanil in mouse two-stage liver carcinogenesis model(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
• Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
• L-Type Amino Acid Transporter-1 Expressed in Human Astrocytomas, U343MGa(Biochemistry)
• Transport of methylmercury through the epithelial type amino acid transport system B^0(Proceedings of the 32nd Annual Meeting)
• P7-56 Identification of novel system L transporters and their methyl mercury-cysteine conjugates transport properties(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
• P7-20 Modulatory effects of membrane proteins interacting with essential large neutral amino acids transporter LAT1, on amino acid uptake in bladder transitional cell carcinoma line, T24(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTO
• Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
• Expression of Sialic Acid Residues in Renal Tubule of Streptozotocin-induced Diabetes Rats
• P-21 Trasport of methyl mercury-cysteine conjugate by multispecific organic anion transport 3(Proceedings of the 27th Annual Meeting)
• Establishment of a Mouse Macula Densa Cell Line with an nNOS Promoter Driving EGFP Expression
• Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate
• Nicergoline Enhances Glutamate Uptake via Glutamate Transporters in Rat Cortical Synaptosomes(Highlighted paper selected by Editor-in chief)(Pharmacology)
• Measurement of Glutamate Uptake and Reversed Transport by Rat Synaptosome Transporters(Pharmacology)
• Correlation of angiogenesis with ^F-FMT and ^F-FDG uptake in non-small cell lung cancer
• Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung
• L-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
• Nephrin and Podocin Expression Around the Onset of Puromycin Aminonucleoside Nephrosis
• RELATIONSHIP BETWEEN γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY IN URINE AND RENAL PROXIMAL TUBULAR DAMAGE(S) BY NEPHROTOXIC AGENTS (The 6th Meeting for the Study of Toxic Effect)
• SUPPRESSIVE EFFECT OF DIPYRIDAMOLE ON THE PROTEINURIA OF AMINONUCLEOSIDE NEPHROSIS IN RAT.
• EFFECTS OF MERCURY ON THE STRUCTURAL GLYCOPROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The 5th Meeting for the Study of Toxic Effect)
• EFFECTS OF MERCURY ON THE STRUCTURAL PROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The Fourth Meeting for the Study of Toxic Effect)
• 215. TOXIC ACTION OF HEAVY METALS. 2. ANALYSIS OF PROTEINURIA DUE TO MERCURY (The Third Meeting for the Study of Toxic Effect)
• 103. EFFECT OF MERCURY ON THE NEWT KIDNEY (The Second Meeting for the Study of Toxic Effect)
• PROGRESS IN NEPHROTOXICOLOGY : FROM IN VIVO SCREENING TEST TO MOLECULAR MECHANISMS
• Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
• Expression of Human Organic Anion Transporters in the Choroid Plexus and Their Interactions With Neurotransmitter Metabolites
• Role of Organic Anion Transporters in the Tubular Transport of Indoxyl Sulfate and the Induction of its Nephrotoxicity.(GENERAL SESSION BY POSTER PRESENTATION)(KIDNEYS AND URINARY EXCRETION SYSTEM)
• Induction of rat hepatic CYP 1A1, 1B1, and AhR by 7, 12-dimethylbenz[α]anthracene on prenatal 3, 3', 4, 4', 5-pentachlorobiphenyl exposure(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Evaluation of testicular toxicology in aging rats with prenatal exposure for 3, 3', 4, 4', 5-pentachlorobiphenyl(Proceedings of the 32nd Annual Meeting)
• Evaluation of testicular toxicology in puberty to adult rats with prenatal exposure for 3, 3', 4, 4', 5-pentachlorobiphenyl(Proceedings of the 32nd Annual Meeting)
• N-methyl-N-nitrosourea induced rat prostate carcinogenesis is modulated by prenatal 3, 3', 4, 4', 5-pentachlorobiphenyl exposure(Proceedings of the 32nd Annual Meeting)
• Initial Changes of Hepatic Glycogen Granules and Glycogen Phosphorylase a After Exposure to 7,12-dimethylbenz[a]anthracene in Rats
• Differential Expression of System L Amino Acid Transporters during Wound Healing Process in the Skin of Young and Old Rats(Molecular and Cell Biology)
• Expressions of CYP1A1mRNA and CYP1B1mRNA in Dimethylbenz(a)anthracene (DMBA) induced Rat Mammary Carcinoma after Prenatal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126).(GENERAL SESSION BY ORAL PRESENTATION)(CARCINOGENICITY)
• O11-11 In-Utero and Lactational Exposure of Low dose 3, 3', 4, 4', 5-Pentachlorobiphenyl(PCB126)Enhance Dimethlbenz[a]anthracene(DMBA)-induced Mammary Carcinogenesis in the Rat.
• VASCULAR ENDOTHELIAL GROWTH FACTOR MODULATE MICROVESSELS IN BBN-INDUCED RAT BLADDER CARCINOMA
• O-58 Transport of a methylmercury-cysteine conjugate mediated by system L neutral amino acid transporters(Proceedings of the 27th Annual Meeting)
• Human Organic Anion Transporters Mediate the Transport of Tetracycline
• C-17 IDENTIFICATION OF A NOVEL LIVER SPECIFIC ORGANIC ANION TRANSPORTER SELECTIVE FOR CONJUGATED DRUGS AND STEROID HORMONES
• Testicular Toxicology of Pubescent and Adult Rats Prenatally Exposure to 3,3',4,4',5-Pentachlorobiphenyl
• Expression of a system L amino acid transporter at testis of rats after prenatal exposure to di(n-butyl)phate(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
• Microarray Analysis for Angiogenesis in Rat Experimental Granulation Tissue (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• The role of amino acid transporters in the cytotoxicity of methylmercury.(GENERAL SESSION BY POSTER PRESENTATION)(ENVIRONMENTAL CHEMICALS,HEAVY METALS & CYTOTOXICITY)
• O10-17 Expression of system L amino acid transporters in the blood-tissue barriers and the transport of 35^S-methylmercury.
• Role of Mouse Organic Anion Transporter 3 (mOat3) as a Basolateral Prostaglandin E_2 Transport Pathway
• Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules
• BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells(Molecular and Cell Biology)
• FUNCTIONAL PROPERTIES OF MULTISPECIFIC AMINO ACID TRANSPORTERS AND THEIR IMPLICATIONS TO TRANSPORTER-MEDIATED TOXICTY
• Organic Anion Transporter Family : Current Knowledge
• System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells
• Purinoceptor-Mediated Calcium Mobilization and Cellular Proliferation in Cultured Bovine Corneal Endothelial Cells
• Molecular biology of multispecific organic anion transporter family (OAT family)
• 22D-09-3 Silica increases cytosolic calcium and causes cell injury in renal cell lines.
• Effects of hexavalent chromium on lipid peroxidation and hydroxyl radical generation in mouse kidney.
• Functional Characterization and Immunohistochemical Localization of Organic Anion Transporter 1 (S1c22a6) from Mouse Kidney
• NARCOTIC PHYSICAL DEPENDENCE AND URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
• Current Status and Future Perspective on Molecular Toxicology (KEYNOTE LECTURE) (Proceedings of the 30th Annual Meeting)
• B-12 EFFECT OF MERCURY CHLORIDE ON ANGIOTENSIN II-INDUCED [Ca^]_i INCREASE IN RAT EARLY PROXIMAL TUBULE
• Cis-platinum(II)-diamino dichloride(CDDP) induced toxicity in immortalized cell lines established from each nephron segment of transgenic mice harboring ts-SV40 T-antigen gene.
• Roles of glutamate transporters in neuronal cell death
• W2-1 SIGNIFICANCE OF ALTERNATIVE TOXICITY TESTING
• Human Nramp2 as a cadmium transporter.(GENERAL SESSION BY POSTER PRESENTATION)(ENVIRONMENTAL CHEMICALS,HEAVY METALS & CYTOTOXICITY)
• EVALUATION OF NEPHROTOXICITY
• DISTRIBUTION AND SOME CHARACTERISTICS OF CYTOCHROME P-450 IN THE KIDNEY
• "C-14 The intracellular mechanism for cisplatin-induced apoptosis in renal cell line
• L-Type amino acid transporter 1 inhibitors inhibit tumor cell growth
• Interactions of Human-and Rat-Organic Anion Transporters With Pravastatin and Cimetidine
• Transport of ochratoxin A by renal multispecific organic anion transporter 1 and its effect on cell proliferation
• L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer
• Prediction of clinically insignificant prostate cancer by detection of allelic imbalance at 6q, 8p and 13q
• Cyclin D1/cdk4, estrogen receptors α and β, in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study
• Interactions of Human Organic Anion Transporters With Aristolochic Acids
• DISTRIBUTION OF GAMMA-GLUTAMYL TRANSPEPTIDASE AND GLUTAMINASE ISOENZYMES IN THE RABBIT SINGLE NEPHRON
• MICROPUNCTURE STUDY OF PROTEIN CONCENTRATION IN GLOMERULAR FLUID IN THE NEWT
• CYTOCHROME P-450 MONOOXYGENASE SYSTEM IN THE RABBIT KIDNEY: ITS INTRANEPHRON LOCALIZATION AND ITS INDUCTION
• Interactions of Human Organic Anion Transporters With Aristolochic Acids
• Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
• Cyclin D1/cdk4, estrogen receptors α and β, in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis : immunohistochemical study
• Human urate transporter 1 (hURAT1) mediates the transport of orotate
• Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
• Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
• A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A
• Capillary Fenestration in N-butyl-N-(4-hydroxybutyl) nitrosamine-induced Rat Bladder Carcinoma is Promoted by Vascular Endothelial Growth Factor
• In-Utero and Lactational Exposure of 3,3',4,4',5-Pentachlorobiphenyl Modulate Dimethlbenz[a]anthracene-Induced Rat Mammary Carcinogenesis

もっと見る 閉じる

スポンサーリンク