Expression of Sialic Acid Residues in Renal Tubule of Streptozotocin-induced Diabetes Rats
スポンサーリンク
概要
- 論文の詳細を見る
The distribution of sialic acid residues in renal tubule of streptozotocin-induced diabetes rats was investigated using lectin histochemical method to compare with specimens from control animals. Sialic acid specific lectins, Limax flavus (LFA), Sambucus nigra (SNA), and Maackia amurensis (MAA) were applied. This sialic acid residues of the renal tubule in diabetes rats were markedly different from those in the control. The epithelial cells of the entire proximal tubule in normal rats were positive for LFA and SNA, and negative for MAA. Meantime, the proximal tubule in diabetes rats was negative for these lectins. The medullary thick ascending limb in normal rats showed negative for LFA, SNA and MAA. In contrast, that limb in diabetes rats showed positive for these lectins. Moreover, the degenerated epithelial cells in the cortical thick ascending limb were intensely positive for LFA and MAA, and negative for SNA. The present study revealed that the different distribution of epithelial sialic acid residues in the renal tubule might be related to the functional diversity exhibited by these tubular regions between diabetic and normal rats.
- 日本毒性病理学会の論文
- 1998-03-01
著者
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鷹橋 浩幸
Department of Pathology, The Jikei University School of Medicine
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古里 征国
Dept. Pathol. Kyorin Univ. Sch. Med. Kyorin Univ. Sch. Med.
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鷹橋 浩幸
Dept. Pathol. Jikei Univ. Sch. Med.
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鷹橋 浩幸
麻布大学 獣医
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牛込 新一郎
Department Of Pathology Jikei University School Of Medicine
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政岡 俊夫
麻布大学獣医学部
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武藤 朋子
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Muto Tomoko
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Muto Tomoko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Muto Tomoko
Comparative Toxicology Laboratories Azabu University School Of Veterinary Medicine
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和久井 信
Department Of Toxicology Azabu University School Of Veterinary Medicine
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和久井 信
麻布大学 獣医
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政岡 俊夫
Comparative Toxicology Laboratories Azabu University School Of Veterinary Medicine
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政岡 俊夫
麻布大学 獣医
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Takahashi Hiroyuki
Department Of Pathology The Jikei University School Of Medicine
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鷹橋 浩幸
Department Of Pathology The Jikei University School Of Medicine
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和久井 信
Comparative Toxicology Laboratories, Azabu University School of Veterinary Medicine
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古里 征国
Department of Pathology, Kyorin University School of Medicine
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武藤 朋子
Comparative Toxicology Laboratories, Azabu University School of Veterinary Medicine
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佐々木 慎二
Comparative Toxicology Laboratories, Azabu University School of Veterinary Medicine
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佐々木 慎二
Comparative Toxicology Laboratories Azabu University School Of Veterinary Medicine
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古里 征国
Department Of Pathology Jikei University School Of Medicine
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