Cyclin D1/cdk4, estrogen receptors α and β, in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study
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概要
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Hyperproliferative cell growth due to cyclin D1/cdk4, marker of cellular proliferation, is considered to be regulated by the expression of estrogen receptors (ERs). We investigated the immunohistochemical expression of cyclin D1/cdk4 and ERs in N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)-induced rat gastric carcinogenesis. The gastric cancer incidence and expression of cyclin D1/ckd4 in gastric carcinogenesis were significantly higher in males than females. Although the ERα expression index was similar in both sexes, the ERβ expression in preneoplastic hyperplastic lesions as well as gastric cancers was significantly higher in females than in males. The present study revealed a gender difference in MNNG-induced rat gastric carcinogenesis that seemed to involve the sex difference in cyclin D1/cdk4 expression, and ERβ expression became evident at the preneoplastic promotion stage in gastric carcinogenesis.
著者
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武藤 朋子
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Muto Tomoko
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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和久井 信
Department Of Toxicology Azabu University School Of Veterinary Medicine
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和久井 信
麻布大学 獣医
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WAKUI Shin
Department of Toxicology, Azabu University School of Veterinary Medicine
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MOTOHASHI Masaya
Department of Toxicology, Azabu University School of Veterinary Medicine
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SUZUKI Yoshihiko
Department of Toxicology, Azabu University School of Veterinary Medicine
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HANO Hiroshi
Department of Pathology, The Jikei University School of Medicine
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Takahashi Hiroyuki
Department Of Pathology The Jikei University School Of Medicine
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Wakui Shin
Department Of Toxicology Azabu University School Of Veterinary Medicine
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Hano Hiroshi
Department Of Pathology 1 Jikei University School Of Medicine
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SHIRAI MASARU
Department of Pediatrics, Asahikawa Kosei Hospital
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Motohashi Masaya
Department Of Toxicology Azabu University School Of Veterinary Medicine
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Shirai Masaru
Department Of Pediatrics Asahikawa Kosei Hospital
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Suzuki Yoshihiko
Department Of Biochemistry School Of Veterinary Medicine Azabu University
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Muto Tomoko
Yoshimi Laboratory, Drug Safety Testing Center Co., Ltd
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Suzuki Yoshihiko
Department Of Biochemistry And Cell Biology Institute Of Development And Aging Sciences Graduate Sch
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Motohashi Masaya
Department Of Toxicology And Biochemistry Azabu University School Of Veterinary Medicine
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