Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed In Utero to Di(n-butyl) Phthalate
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概要
- 論文の詳細を見る
We recently reported that prenatal rat exposure to di(n-butyl) phthalate (DBP) induced Leydig cell (LC) hyperplasia after nine weeks (wks) of age, yet the number of LCs was similar to that of the vehicle group until seven weeks. Nuclear pleomorphism of hyperplastic LCs is common and is considered to be continuous progressive degeneration. Thus, computer-assisted image cell nuclear analysis of LCs was performed on 5- and 7-wk-old Sprague-Dawley (SD) rats whose dams had been administered DBP (i.g.) at 100 mg/kg/day or vehicle (corn oil) on gestation day 12 to 21. The results of the 5-wk-old DBP group were similar to those of the vehicle group; LC nuclei of the 7-wk-old DBP group showed normal ploidy and similar amounts of DNA. However, the size, elongation and peripheral chromatin aggregation parameters were significantly higher, and the reticular chromatin distribution and isolated chromatin aggregation parameters were significantly lower compared with the vehicle group. The present study quantitatively demonstrated nuclear morphological alterations in rat LCs at 7 wks old (puberty) due to the prenatal DBP administration before apparent LC hyperplasia developed.
- 日本毒性病理学会の論文
著者
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Shirai Masaru
Department Of Pediatrics Asahikawa Kosei Hospital
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ASARI Masao
Department of Anatomy 1, School of Veterinary Medicine, Azabu University
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Wempe Michael
School Of Pharmacy University Of Colorado Health Sciences Center
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Motohashi Masaya
Department Of Toxicology And Biochemistry Azabu University School Of Veterinary Medicine
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Takahashi Hiroyuki
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Wakui Shin
Department of Toxicology and Biochemistry, Azabu University School of Veterinary Medicine
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Motohashi Masaya
Department of Toxicology, Laboratory Animal Science, and Veterinary Anatomy, Azabu University School of Veterinary Medicine, 1-17-71 Chuo, Sagamihara, Kanagawa 252-5201, Japan
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Endou Hitoshi
J-Pharma Co., Ltd., 75-1 Turumi, Kanagawa 230-0046, Japan
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Satoh Takemi
Kokusan Co., Ltd., 7-8-16 Nishibori Sakura, Saitama 338-0832, Japan
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Mutou Tomoko
Drug Safety Testing Center, 25-1 Kuroiwa, Yoshimi Hiki, Saitama 335-0116, Japan
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Inomata Tomoo
Department of Toxicology, Laboratory Animal Science, and Veterinary Anatomy, Azabu University School of Veterinary Medicine, 1-17-71 Chuo, Sagamihara, Kanagawa 252-5201, Japan
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