Pathomechanism of Cellular Infiltration in the Perivascular Region of Several Organs in SAMP1/Yit Mouse
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概要
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We investigated the histological changes of extra-intestinal organs, such as the liver, kidney, lung and pancreas in SAMP1/Yit mice, a human Crohns disease model, using immunohistochemical techniques. The perivascular cellular infiltration was detected around the small vessels after 30 weeks. These infiltrating cells consisted of many CD4-positive T-lymphocytes, and small numbers of CD8- positive T-lymphocytes and IgG-positive B-lymphocytes. MAdCAM-1 and VCAM-1 were detected in vascular endothelial cells in non-affected regions of 13 and 20 week-old, as well as in the affected regions showing perivascular cellular infiltration after 30 weeks. In addition, integrin α4β7 was detected on these infiltrating cells in the perivascular regions after 30 week-old. LT-β and IL-12, cytokines of the Th-1-type immune response, were not observed in these affected regions. However, IL-4, one of the cytokines of the Th-2-type immune response, was detected on the perivascular infiltrating cells after 30 week-old. These results revealed that the changes in extra-intestinal organs were mainly caused by infiltration of CD4-positive T-lymphocytes into the perivascular regions in SAMP1/Yit mice. These cellular infiltrations were thought to be initiated by adhesion of CD4-positive T-lymphocytes to the endothelial cells mediated by MAdCAM-1 and integrin β7. Immunohistochemistry for Th related cytokines indicated that the perivascular cellular infiltration was developed by the Th-2-type immune response in the extra-intestinal organs of SAMP1/Yit mouse.
- 社団法人 日本獣医学会の論文
著者
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Soeta Satoshi
Department of Veterinary Anatomy, Nippon Veterinary and Animal Science University
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AMASAKI Hajime
Department of Veterinary Anatomy, Nippon Veterinary and Animal Science University
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ICHIHARA Nobutsune
Department of Animal Models for Human Disease, National Institute of Neuroscience, NCNP
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Soeta Satoshi
麻布大学 解剖学
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Soeta Satoshi
Department Of Veterinary Anatomy Nippon Vetrinary And Animal Science University
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Amasaki Hajime
Department Of Veterinary Anatomy Nippon Veterinary & Animal Science University
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Ichihara Nobutsune
Department Of Anatomy I School Of Veterinary Medicine Azabu University
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Ichihara Nobutsune
麻布大学 解剖学
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MATSUMOTO Satoshi
Yakult Central Institute for Microbiological Research
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CHOSA Mizuki
Department of Anatomy 1, School of Veterinary Medicine, Azabu University
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NISHITA Toshiho
Department of Physiology 1, School of Veterinary Medicine, Azabu University
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ASARI Masao
Department of Anatomy 1, School of Veterinary Medicine, Azabu University
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ICHIHARA Nobutsune
Department of Anatomy 1, School of Veterinary Medicine, Azabu University
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SOETA Satoshi
Department of Veterinary Anatomy, Nippon Veterinary & Life Science University
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