Mucosal Immune Responses to the Introduction of Gut Flora in Mice and the Establishment of a Murine Model of Crohn's Disease

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概要

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• Gut flora plays a key role in the maturation of intestinal mucosal immune systems such as the expression of class II MHC antigens on intestinal epithelial cells, and the cell expansion and functional maturation of both IgA-producing B lymphocytes in the lamina propria and TCR αβ-expressing intraepithelial lymphocytes in the intestinal epithelium in mice. In normal mice, the mucosal immune responses evoked through colonization of gut flora attained levels found in mice reared under normal gut flora-bearing conditions. However, in SAMP1/Yit mice, recently established as a murine model of Crohns disease, transmural ileitis and cecetis developed following the introduction of commensal gut flora from normal mice, although no intestinal inflammation was observed under germfree conditions. These results suggested that commensal gut flora play critical roles in the development of Crohns disease-like intestinal inflammation in SAMP1/Yit mice. In this review, we focus on the specific interactions between the gut flora and mucosal immune systems that induce physiological or unphysiological mucosal immune responses.

• 2004-01-01

著者

• MATSUMOTO Satoshi

  Yakult Central Institute for Microbiological Research

関連論文

• Segmented Filamentous Bacteria Are Indigenous Intestinal Bacteria That Activate Intraepithelial Lymphocytes and Induce MHC Class II Molecules and Fucosyl Asialo GM1 Glycolipids on the Small Intestinal Epithelial Cells in the Ex-Germ-Free Mouse
• Pathomechanism of Cellular Infiltration in the Perivascular Region of Several Organs in SAMP1/Yit Mouse
• Mucosal Immune Responses to the Introduction of Gut Flora in Mice and the Establishment of a Murine Model of Crohn's Disease
• Enteric Bacteria and Their Roles in Inflammatory Bowel Disease

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